pain and anesthetics #8 Flashcards Preview

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Flashcards in pain and anesthetics #8 Deck (53):
1

Congenital analgesia?

Cannot feel pain, but can feel touch, not always Temp.

2

Men have more?
Women have more?

back pain, cluster headaches
Migraines, UTIs, carpal tunnel

3

Acute pain vs Chronic (% of pop.)?

Results from inflammation/injury and goes away, other persist. 25 >65years old

4

Can Pain become a disease?

Yes when touches spinal cord and rewires itself

5

Lebenswecker?

Tool to riderect pain with needles.

6

Morpheus god of?

Sleep

7

%of women orthopedic surgeons nowaday?

5-10%

8

1st anesthetic? Possible founders?

EtOH heated with acid = Sweet vitriol = Ether/Diethyl ether + H2O
Raymunus 1200s
Paracelsus

9

Joseph Priestley 1772 first to make? How?

N2O/Nitrous oxide. Heat ammonium nitrate (fertilizer and explosive) -> N2O + 2 H2O

10

Sir Humprey Davy 1800s discovered?

Breath N2O = euphoric effect (Whipping cream)

11

William T.G. Morton 1844?
Horace Wells 1844?
Is an example of?

Used ether inhaler in op.
First, op with N2O (tooth removal)
Simultaneous discovery

12

Dr. Crawford Long 1848?

First, op with ether

13

Letheon=

Ether

14

John Collin William 1840s

Let Morton use anesthetics when he operated

15

2 biggest op in 1800s?

Amputation, surface tumors

16

Humbug?

When pt left during b/c too much pain.

17

Press celebrated ether as?

Diminishing pain

18

Who and how he killed houdini?

McGill student by punching him in the stomach and supposedly caused him an appendicitis .

19

Robert Houdini supposedly?

Used ether to induce euphoria to public during levitation.

20

James Simpson invented? date

Chloroform 1847

21

Queen Victoria 1853 was the first to?

Anesthetized during 8th child, contreversy at the time

22

Apoplexy=

uncounsciousness or incapacity = stroke

23

Who gets most credit for discovery of anesthetics?why?

Dr. Crawford Long, b/c he published

24

Other early anesthetic?

Potassium Bromide

25

Dr. Harold Randall Griffith?

1st to used curare in operation in 1942 at McGill

26

Curare plant?

Chondrodendron Tomentosum

27

Preanesthetics Rx.

Atropine = block secretions
Demerol = sedation

28

Iv anethetics?

Tiopental sodium; fentanyl (100% more potent then morphine)

29

Basic structure of opioids?

Benzene ring + 2 C + N

30

2016 dead opiod overdose USA?

65 000, more than car

31

Subsys?

Spray fentanyl

32

1890 lancet physician opinion on hemp?

Best pain managment

33

Propofol comes from?

Thymol (found in listerine) close to phenol

34

Ane. mac of action?

Not clear, change in neurons membranes transmission

35

Poppy exsudat [] %?

10% morphine, 19% codeine

36

TReat, addict in myanmar?

Public vomiting

37

Heroin world prod?

Afghanistan and Myanmar

38

2001 in afgha?

Fatwa on heroin, prod decreased, now back up.

39

Found in urine after poppy and heroin intake

Thebaine

40

Laudanum=

opium

41

Andersonville Prison Gergio during civil war 1860?

Morphine was brought to ease pain

42

Anecdote of Dr. HArold Shipmen?

Killed more than 200 women using morphine

43

effort to control oxycodone?

RFID on bottle

44

Morphine isolated in?
Synthetized in?

1805
1942

45

2 acetyl group on morphine =?

Heroin, quicker high, converted into morphine in the body

46

Opioids ant?

Naltrexone/naloxone

47

Bernard Belleau mcgill invented?

Stradol (Butorphanol), less addiction, vet. use

48

Endogenous opiods formation?

B-Lipotropin (polypeptide) ->Endorphin
Enkephalin (cannot be given in pills)

49

PLacebo?

Expectation of pain relief = open u-opiod receptor

50

GAte control theory?

Pain signal interfered by stimulating nerve ending responsible for pain, stimulating endoprhins

51

Chinese red headed centiped?

Venom block Na+ channel linked to pain

52

Comes from frog-epibatidine?

ABT-594 - as effective as morphine

53

Comes from Cone Shell venom?

Zincontide, block pain channels, when put into spinal cord, 500X more potent than morphine