Flashcards in pain and anesthetics #8 Deck (53):
Cannot feel pain, but can feel touch, not always Temp.
Men have more?
Women have more?
back pain, cluster headaches
Migraines, UTIs, carpal tunnel
Acute pain vs Chronic (% of pop.)?
Results from inflammation/injury and goes away, other persist. 25 >65years old
Can Pain become a disease?
Yes when touches spinal cord and rewires itself
Tool to riderect pain with needles.
Morpheus god of?
%of women orthopedic surgeons nowaday?
1st anesthetic? Possible founders?
EtOH heated with acid = Sweet vitriol = Ether/Diethyl ether + H2O
Joseph Priestley 1772 first to make? How?
N2O/Nitrous oxide. Heat ammonium nitrate (fertilizer and explosive) -> N2O + 2 H2O
Sir Humprey Davy 1800s discovered?
Breath N2O = euphoric effect (Whipping cream)
William T.G. Morton 1844?
Horace Wells 1844?
Is an example of?
Used ether inhaler in op.
First, op with N2O (tooth removal)
Dr. Crawford Long 1848?
First, op with ether
John Collin William 1840s
Let Morton use anesthetics when he operated
2 biggest op in 1800s?
Amputation, surface tumors
When pt left during b/c too much pain.
Press celebrated ether as?
Who and how he killed houdini?
McGill student by punching him in the stomach and supposedly caused him an appendicitis .
Robert Houdini supposedly?
Used ether to induce euphoria to public during levitation.
James Simpson invented? date
Queen Victoria 1853 was the first to?
Anesthetized during 8th child, contreversy at the time
uncounsciousness or incapacity = stroke
Who gets most credit for discovery of anesthetics?why?
Dr. Crawford Long, b/c he published
Other early anesthetic?
Dr. Harold Randall Griffith?
1st to used curare in operation in 1942 at McGill
Atropine = block secretions
Demerol = sedation
Tiopental sodium; fentanyl (100% more potent then morphine)
Basic structure of opioids?
Benzene ring + 2 C + N
2016 dead opiod overdose USA?
65 000, more than car
1890 lancet physician opinion on hemp?
Best pain managment
Propofol comes from?
Thymol (found in listerine) close to phenol
Ane. mac of action?
Not clear, change in neurons membranes transmission
Poppy exsudat  %?
10% morphine, 19% codeine
TReat, addict in myanmar?
Heroin world prod?
Afghanistan and Myanmar
2001 in afgha?
Fatwa on heroin, prod decreased, now back up.
Found in urine after poppy and heroin intake
Andersonville Prison Gergio during civil war 1860?
Morphine was brought to ease pain
Anecdote of Dr. HArold Shipmen?
Killed more than 200 women using morphine
effort to control oxycodone?
RFID on bottle
Morphine isolated in?
2 acetyl group on morphine =?
Heroin, quicker high, converted into morphine in the body
Bernard Belleau mcgill invented?
Stradol (Butorphanol), less addiction, vet. use
Endogenous opiods formation?
B-Lipotropin (polypeptide) ->Endorphin
Enkephalin (cannot be given in pills)
Expectation of pain relief = open u-opiod receptor
GAte control theory?
Pain signal interfered by stimulating nerve ending responsible for pain, stimulating endoprhins
Chinese red headed centiped?
Venom block Na+ channel linked to pain
Comes from frog-epibatidine?
ABT-594 - as effective as morphine