Class 7 Respiratory 3 Flashcards
(36 cards)
Allergic Rhinitis
A group of signs and symptoms, mainly in the nose and eyes, triggered by inhaling allergens
Names for allergic rhinitis
- Hay fever
- Seasonal allergies
Allergic Rhinitis common comorbidities
- Asthma
- Atopic dermatitis - Atopy
Allergic Rhinitis Pathogenesis
An acute vasomotor response caused by histamine and related substances released locally in the nose from IgE-coated mast cells.
Allergic Rhinitis Clinical Manifestations
Itchy nose and mouth, conjunctivitis, sneezing, sinus and nasal obstruction, coughing, wheezing, and coryza.
Allergic Rhinitis Diagnosis
History, symptoms, and skin test.
Allergic Rhinitis Treatments
Avoid triggers, antihistamines, decongestants, and injections.
Asthma
- Increased bronchial responsiveness to stimuli, classified as reversible COPD
- chronic inflammatory condition with acute exacerbations
- complex disorder involving biochemical, autonomic, immunologic, infectious, endocrine, and psychological factors.
Asthma Incidence
The most common chronic disease in adults and children, more prevalent in males (2:1)
Extrinsic Asthma
Results from an allergy to specific triggers, primarily affecting children and young adults, and classified as hypersensitivity disorders.
Intrinsic Asthma
No known triggers, adult onset, possibly related to viral exposure, and referred to as post-viral asthma
Occupational Asthma
Narrowing of the airways caused by workplace exposure
Exercise-Induced Asthma
Bronchoconstriction can occur in individuals without other forms of asthma, affecting up to 20% of the healthy population, and is more common in cold temperatures.
Asthma Pathogenesis
An inflammatory response in the airway causes:
Cellular infiltration, epithelial disruption, mucosal edema, and mucous plugging
Asthma Pathogenesis
The inflammatory mediators produce:
Smooth muscle spasm, vascular congestion, increased vascular permeability, edema formation, production of thick mucous, and impaired mucociliary function
Asthma Pathogenesis
Mediators also cause
- Thickening of airway walls
- Increased contractile response of bronchial smooth muscle
Asthma Pathogenesis:
Airway hyper-responsiveness, swollen airways, and mucous plugs lead to distal air trapping, resulting in:
Hypoxemia, obstructed airflow, and increased work of breathing.
Asthma Clinical Manifestations
⬧Variation
Variation in presentation, cough, shortness of breath (SOB), wheezing, degree (mild, moderate, severe), and frequency.
Asthma Clinical Manifestations Duration
- Most attacks are short-lived with asymptomatic periods in between.
- Repeated episodes may lead to barrel chest, elevated shoulders, and hypertonicity of accessory muscles.
- Acute severe asthma (formerly status asthmaticus) is an unresponsive attack requiring emergency care and can be fatal.
Asthma Diagnosis
History, clinical manifestation, and pulmonary function tests (FEV-1).
Asthma Treatment
Identify and avoid specific triggers, and use medications such as corticosteroids and bronchodilators.
Asthma Prognosis
- Asthma may resolve in many children, but for about one in four, wheezing persists into adulthood or relapses later.
- Approximately 4,000 deaths per year in the U.S. are asthma-related, most of which are preventable with treatment, leading to a good prognosis with proper access and adherence.
- Over time, some patients may experience permanent airway remodeling, hindering normal lung function; early aggressive use of anti-inflammatory drugs may help prevent this
PNEUMOCONIOSES
Restrictive lung diseases caused by inhalation of mineral dusts and inorganic particulates, resulting in permanent deposition of substantial amounts of particles in the lungs, particularly from inorganic dust like iron ore or coal.
PNEUMOCONIOSES Classification
Most are classified as occupational diseases resulting from long-term workplace exposure, with the most common being coal worker’s pneumoconiosis (anthracosis), silicosis, and asbestosis.
