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Clinic-IBD Flashcards

(58 cards)

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1
Q

colon only

A

UC

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2
Q

focal and patchy

A

CD

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3
Q

transmural inflammation

A

CD

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4
Q

occurs in smokers

A

CD

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5
Q

diffuse and contiguous

A

UC

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6
Q

can present with perianal sx, fistulas, and/or granulomas

A

CD

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7
Q

both UC and CD are more prevalent in the (North/South)

A

North

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8
Q

age of onset for IBD

A

15-30

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9
Q

females are more likely to get this one

A

CD

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10
Q

whites and jewish more likely to get this one

A

UC

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11
Q

associated with chromosome 16 mutation (NOD2)

A

CD

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12
Q

smoking may have a protective effect for this one

A

UC

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13
Q

appendectomy may be protective for this one

A

UC

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14
Q

incidence of IBD peaks at what two points in life

A

20, 50

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15
Q

IBD is more prevalent in the developing/developed world

A

developed

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16
Q

theory behind IBD

A

overly aggressive T cell response directed against environment and/or commensal bacteria

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17
Q

chronic inflammation in IBD is due to an imbalance between?

A

pro- and anti-inflammatory mediators

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18
Q

dysbiosis

A

both

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19
Q

hygeine hypothesis of IBD

A

increase hygeine = decreased development of immune system as child = imbalance between Th1 and Treg cells

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20
Q

genetics associated with CD relate to?

A

microbe recognition, innate immune system

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21
Q

genetics associated with UC relate to?

A

HLA genes, intestinal barrier integrity

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22
Q

____ allelic variants seen in 27-39% of CD pts, confers worse dz and earlier onset

A

NOD2

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23
Q

role of NOD2 protein

A

recognition of microbes and innate immunity

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24
Q

extra-intestinal manifestations of IBD occur in? (4 places)

Study These Flashcards
A

skin, liver, eyes, joints

25
70% of CD involves what part of the intestines?
ileum
26
clinical presentation of crohn's (6 things)
abdominal pain, diarrhea, weight loss, growth retardation, fever, perianal dz
27
SBFT of CD shows?
high grade strictures (inflammation in bowel)
28
CT of CD shows?
thickened wall
29
linear ulcers in SB sign of?
CD
30
skip lesions
CD
31
2 major complications of CD
obstruction, fistulas (abscesses)
32
signs of obstruction
cramps, distension, vomiting
33
removal of the terminal ileum may cause?
B12 deficiency, bile salt diarrhea, fat malabsorption if >100cm
34
clinical presentation of UC (6 things)
bloody diarrhea, tenesmus, crampy abdominal pain with BM, weight loss, fever, growth retardation
35
if concerned about UC, always do an X-ray to rule out?
toxic megacolon
36
UC is dx by?
sigmoidoscopy or colonoscopy
37
___ increases risk of colorectal cancer (significant risk by ___ years after diagnosis)
UC; 30 (screen at 10 years)
38
___ (from last exam) is a risk factor for colorectal ca in pts with UC
PSC
39
surgical tx of UC
proctocolectomy (koch pouch or ileal pouch anal anastomosis)
40
skin disorders in IBD
erythema nodosum, pyoderma gangrenosum, cutaneous CD
41
MSK disorders in IBD
peripheral arthritis, sacroileitis (central arthritis), ankylosing spondylitis (back pain)
42
this MSK disorder parallels gut dz, the others do not
peripheral arthritis
43
name 2 ocular disoders seen in IBD; which is worse?
uveitis & scleritis; uveitis is worse (both are inflammation)
44
name 4 hepatobiliary disorders associated with IBD
PSC, pericholangitis, cholangiocarcinoma, gallstones
45
name 2 additional EIMs seen in IBD
mouth ulcers, DVT/PE
46
blood in stool
UC
47
mucus
UC
48
systemic symptoms
CD
49
pain
CD
50
abdmominal mass
CD
51
perineal/perianal dz
CD
52
fistulas
CD
53
small intestine/colonic obstruction
CD
54
response to ABX
CD
55
surgery is effective for (UC/CD)
UC
56
cobblestoning
CD
57
granulomas
CD (40-50%)
58
rectal sparing
CD

Gastrointestinal (40 decks)

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