Constipation IBS Flashcards Preview

Gastrointestinal > Constipation IBS > Flashcards

Flashcards in Constipation IBS Deck (25):
1

(men/women) more affected by constipation

women

2

rome III criteria for constipation

less than 3 defecations per week or 25% straining, hard & lumpy, incomplete evacuation, anorectal blockage, or manual assistance (in the ABSENCE of loose stools)

3

this involuntary muscle can sample what is coming

internal anal sphincter

4

name 4 causes of constipation

slow transit, Hisrchprung's, outlet obstruction, anatomic

5

metabolic causes of slow transit

hypothyroidism, diabetes, pregnancy

6

neurogenic causes of slow transit

CVA, MS, Parkinson's

7

medication associated slow transit

narcotics, diuretics, anticholinergics

8

normal transit should take ___ hours to reach the colon, and ___ hours to be defecated

3; 33

9

outlet-type obstructions are due to paradoxical contraction of?

puborectalis and external sphincter

10

Hischprung's is a congenital disorder of ______, due to failure of appropriate migration of ____ cells to the distal rectum

motor neurons; neural crest

11

an absent _____ suggests Hirschprung's dz

RAIR (rectoanal inhibitory reflex)

12

dx of hirschprung's can be done by rectal biopsy and stain for ________

ganglion cells; no cells = hirschprung's

13

tx for slow transit

laxatives (polyethylene glycol, lubiprostone, linaclotide)

14

tx for outlet-type obstruction of anal canal

physical tx for pelvic floor

15

hirschprung's dz tx

surgical management only

16

polyethylene glycol is an _____

osmotic agent

17

lubiprostone is a ______

chloride channel activator

18

linaclotide is a ____

GC agonist (can cause dysentery)

19

this drug does not affect central receptors and thus can be given with narcotic analgesics

methylnaltrexone (prokinetic)

20

IBS responses are modulated by?

neurotransmitters, gut opiate receptors, myoelectric responses

21

management of IBS

sx-based management, phychological tx

22

MoA of fiber

resists enzymatic digestion, presented to colon unchanged, fermented by colonic bacteria to fatty acids = prokinetic

23

this drug is strictly limited to severe, refractory IBS-D and has this major side effect

alosetron (serotonin receptor antagonist); ischemic colitis

24

side effects of antispasmodics (anticholinergics)

constipation, dry mouth, urinary retention, confusion

25

antidepressents: use _____ for IBS-D and _____ of IBS-C

tricyclics; SSRIs