Path-ALD,NALD,DILD Flashcards Preview

Gastrointestinal > Path-ALD,NALD,DILD > Flashcards

Flashcards in Path-ALD,NALD,DILD Deck (15):
1

what is the most common chronic hepatic disorder in the West?

NAFLD

2

radiographic imaging, such as ___ can identify steatosis but it cannot distinguish it from NASH/ASH

CT, US, MRI

3

fatty liver may be (smaller/larger) than a normal liver, and it is (hypo/hyper)dense compared to the spleen

larger, hypodense

4

mild to moderate steatosis shows fat deposition primarily in the ______ region

centrilobular/surrounding central vein (not periportal)

5

early fibrosis in NAFLD shows what pattern?

perisinusoidal (projects from central vein)

6

most severe form of NAFLD

cirrhosis

7

alcoholics absorb more endotoxin from the gut, which activates ______, resulting in _______

Kupffer cells; cytokines TNF-alpha and hepatocyte death

8

why is the centrilobular zone more sensitive to fat deposition?

metabolism of fat requires high O2 and these cells are farthest from the blood supply

9

alcohol metabolites like _____ bind to and alter hepatocyte ___, which stimulates injury

acetaldehyde; proteins

10

what are Mallory bodies (AKA Mallory's hyalin)?

acetaldehyde-induced condensations of cytokeratin filaments within cyto of damaged hepatocytes

11

what is hepatocellular ballooning?

swelling and rounding; accumulation of small-droplet fat in cytoplasm; and dilation of ER

12

how does adipose tissue become inflamed?

proinflammatory factors, cytokines, oxidative stress

13

the risk for progression to cirrhosis and development of HCC are significantly greater when a patient has both fatty liver disease AND _______

hepatitis C

14

major differences between AFLD and NAFLD

history, AST:ALT ratio >2, Mallory bodies all seen in AFLD but not NAFLD

15

the only histological feature relevant to DILI is a predominance of ______ (inflammatory cells)

eosinophils