Flashcards in CLL/SLL Part II Deck (9):
When should we use prophylactic IVIG in CLL patients?
The use of prophylactic IVIG in CLL patients to restore IgG levels is controversial.
IVIG is used in general for those with:
- recurrent infections and whose serum IgG <500 mg/dL
What is Idelalisib?
Phosphoinositide 3-kinase (PI3K) delta inhibitor
What has Idelalisib been associated with?
Serious, potentially fatal diarrhea and/or colitis
Fatal and/or serious hepato-toxicity
Fatal and/or serious pneumonitis
Anemia in CLL - What are the possible reasons?
1) GI Blood loss
- steroids, thrombocytopenia, mucositis, coagulopathy
2) Marrow infiltration with disease
3) Myelosuppression due to treatment
4) Hemolytic anemia
6) Red cell aplasia
What is Evan's syndrome
Immune thrombocytopenia + Concurrent autoimmune hemolytic anemia
Up to 1/3 of CLL patients will have Evan's syndrome
What sort of vaccinations is required s/p splenectomy and when?
2-3 weeks prior to splenectomy
What is Richter's transformation, and how often does it occur?
Richter's transformation = transformation of CLL into an aggressive large-cell lymphoma.
5-10% of CLL patients will have Richter's transformation or prolymphocytic leukemia
Who should not be considered for Fludarabine-based therapy?
Del (17p) mutation
Re-consider if pt > 70 yo