Pathology Flashcards Preview

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Flashcards in Pathology Deck (6):
1

What IHC stains identifies Neuroendocrine differentiation?

CD56
Chromogranin
Synaptophysin

2

What is TTF-1

A homeodomain-containing nuclear transcription protein of the Nkx2 gene family.

Expressed in epithelial cells of the embryonal & mature lung and thyroid

3

What is Napsin A?

An Aspartic proteinase expressed in normal Type II pneumocystis and in proximal and distal renal tubules

4

What are the immunostains relatively sensitive and specific for mesothelioma?

WT-1
Calretinin
D2-40
HMBE-1
Cytokeratin 5/6

5

Which EGFR Exon 20 mutation is sensitive to EGFR TKIs?

EGFR Exon 20 S768I mutation

6

What is acquired resistance to EGFR TKI therapy a/w?

1) Second-site mutations within the EGFR kinase domain (Eg. T790M)
2) Amplification of alternative kinases (eg. MET)
3) Histological transformation from NSCLC to SCLC
4) Epithelial to Mesenchymal transition (EMT)