Flashcards in General Lymphoma Deck (30):
What is the CD Marker for a stem cell?
What are the markers for Granulocyte, monocytes, T-lymphocyte, B-lymphocyte, thrombocytes?
Granulocyte = CD45/CD15
Monocytes = CD45/CD14
T-Lymphocyte = CD45/CD3
B-Lymphocyte = CD45/CD19
Thrombocytes = CD45/CD61
What are the CD markers for Helper T-Lymphocyte, Cytotoxic T-Lymphocyte and Activated T-Lymphocyte?
Helper T-Lymphocyte = CD45/CD3/CD4
Cytotoxic T-Lymphocyte = CD45/CD3/CD8
Activated T-Lymphocyte = CD45/CD3/CD25
What are the CD markers for B Lymphocyte?
What are the CD Markers for NK cell?
CD31, CD30, CD38
How often is the bone marrow involved in lymphoma?
20% High-grade lymphomas
How often does HBV Reactivation occur with cytotoxic chemotherapy ?
20-50% with HBsAg +
3-45% with HBcAb +
What lymphoma is Hep C associated with?
NHL, esp B Cell lymphomas
Tell me about the 5-point scale and PET-CT
The 5-PS is based on the visual assessment of FDG uptake in involved sites relative to the mediastinum and liver.
Score of 1 = no abnormal FDG-avidity
Score of 2 = uptake less than mediastinum
Score of 3 = uptake greater than the mediastinum, but lesser than the liver
Score of 4 = uptake greater than the liver
Score of 5 = uptake greater than the liver and with new sites of disease
Which B cell lymphoma is a/w the highest percentage of patients with Ann Arbor Stage IV?
Small lymphocytic lymphoma/chronic lymphocytic leukemia is the one most commonly a/w stage IV at Dx (80%)
Which virus causes Castleman's disease
Which disease is a/w HHV-8?
What lymphoma is associated with Hep C?
Monocytoid B-cell lymphoma
Which virus is monocytoid B-cell lymphoma a/w?
Which translocation is a/w MALT lymphoma?
- produces Antiapoptotic API2-MLT fusion protein, which is activated as a consequence of the fusion
Translocation t(11;18)q(21;21) is a/w what lymphomas?
What lymphoma is isochrome 7q deletion a/w?
Hepatosplenic T-Cell lymphoma
Which genetic aberration is a/w isochrome 7q deletion?
Hepatosplenic T Cell lymphoma
In CLL/SLL, unmutated Ig V region is a/w aggressive disease. T/F?
Correlates with ZAP-70 expression and CD38 expression
What translocation is a/w lymphoplasmacytic lymphoma?
Translocation t(9;14)(p13;q32) and rearrangement of PAX-5 Gene
Describe Lymphoplasmacytic Lymphomas
Neoplasm of small B lymphocytes, plasmacytoid lymphocytes and plasma cells
- lack CD5, CD10, CD23
- strong expression of sIg and CD20
CLL has: CD10-
What is the most common TCR subtype observed in lymphomas?
TCR gamma-delta is seen hepatosplenic T_Cell lymphoma and some cases of enteropathy-type T-Cell Lymphoma
What is he usual IHC stains for Follicular lymphoma?
Some with nuclear bcl-6+
Where are the common sites of CNS relapse?
Parenchymal brain lesions
What are the risk factors for CNS relapse in patients with aggressive B Cell Lymphoma?
1) Advanced Stage
2) Elevated LDH
3) B symptoms
4) Site - Testis, paranasal, orbit, Bone marrow, breast
5) Epidural lesions
6) young age
Give me example of small B-cell lymphomas
Chronic Lymphocytic Leukemia (CLL)/ Small lymphocytic lymphoma (SLL)
Marginal zone lymphoma
Described T-cell lymphomas morphologically
Heterogeneous population of small, medium-sized, and large neoplastic T cells
When does CD20 expressed ?
Appears later with the light chain rearrangement
What is useful in the diagnostic work-up of T-cell lymphomas?
CD3, CD2, CD 5, CD7 recognize virtually all mature T cells