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Flashcards in General Lymphoma Deck (30):
1

What is the CD Marker for a stem cell?

CD34

2

What are the markers for Granulocyte, monocytes, T-lymphocyte, B-lymphocyte, thrombocytes?

Granulocyte = CD45/CD15
Monocytes = CD45/CD14

T-Lymphocyte = CD45/CD3
B-Lymphocyte = CD45/CD19

Thrombocytes = CD45/CD61

3

What are the CD markers for Helper T-Lymphocyte, Cytotoxic T-Lymphocyte and Activated T-Lymphocyte?

Helper T-Lymphocyte = CD45/CD3/CD4
Cytotoxic T-Lymphocyte = CD45/CD3/CD8

Activated T-Lymphocyte = CD45/CD3/CD25

4

What are the CD markers for B Lymphocyte?

CD45/CD19/CD20
CD24/CD22
CD38

5

What are the CD Markers for NK cell?

CD15
CD56
CD31, CD30, CD38
CD3-

6

How often is the bone marrow involved in lymphoma?

40% Low-grade
40% Intermediate-grade
20% High-grade lymphomas

7

How often does HBV Reactivation occur with cytotoxic chemotherapy ?

20-50% with HBsAg +
3-45% with HBcAb +

8

What lymphoma is Hep C associated with?

NHL, esp B Cell lymphomas

9

Tell me about the 5-point scale and PET-CT

The 5-PS is based on the visual assessment of FDG uptake in involved sites relative to the mediastinum and liver.

Score of 1 = no abnormal FDG-avidity
Score of 2 = uptake less than mediastinum
Score of 3 = uptake greater than the mediastinum, but lesser than the liver
Score of 4 = uptake greater than the liver
Score of 5 = uptake greater than the liver and with new sites of disease

10

Which B cell lymphoma is a/w the highest percentage of patients with Ann Arbor Stage IV?

Small lymphocytic lymphoma/chronic lymphocytic leukemia is the one most commonly a/w stage IV at Dx (80%)

MCL (70%)

PTCL (60%)

11

Which virus causes Castleman's disease

HHV-8

12

Which disease is a/w HHV-8?

Castleman's disease

13

What lymphoma is associated with Hep C?

Monocytoid B-cell lymphoma
Splenic MZL

14

Which virus is monocytoid B-cell lymphoma a/w?

Hep C

15

Which translocation is a/w MALT lymphoma?

T(11;18)q(21:q21)
- produces Antiapoptotic API2-MLT fusion protein, which is activated as a consequence of the fusion

16

Translocation t(11;18)q(21;21) is a/w what lymphomas?

MALT lymphomas

17

What lymphoma is isochrome 7q deletion a/w?

Hepatosplenic T-Cell lymphoma

18

Which genetic aberration is a/w isochrome 7q deletion?

Hepatosplenic T Cell lymphoma

19

In CLL/SLL, unmutated Ig V region is a/w aggressive disease. T/F?

True.
Correlates with ZAP-70 expression and CD38 expression

20

What translocation is a/w lymphoplasmacytic lymphoma?

Translocation t(9;14)(p13;q32) and rearrangement of PAX-5 Gene

21

Describe Lymphoplasmacytic Lymphomas

Neoplasm of small B lymphocytes, plasmacytoid lymphocytes and plasma cells
- lack CD5, CD10, CD23
- strong expression of sIg and CD20

CLL has: CD10-
CD5+, CD23+

22

What is the most common TCR subtype observed in lymphomas?

Alpha-Beta subtype

TCR gamma-delta is seen hepatosplenic T_Cell lymphoma and some cases of enteropathy-type T-Cell Lymphoma

23

What is he usual IHC stains for Follicular lymphoma?

CD10+
CD20+
CD5-
BCL2+ (mostly)
Some with nuclear bcl-6+

24

Where are the common sites of CNS relapse?

Parenchymal brain lesions
Spinal cord
Leptomeningeal
Combinations

25

What are the risk factors for CNS relapse in patients with aggressive B Cell Lymphoma?

1) Advanced Stage
2) Elevated LDH
3) B symptoms
4) Site - Testis, paranasal, orbit, Bone marrow, breast
5) Epidural lesions
6) young age

26

Give me example of small B-cell lymphomas

Chronic Lymphocytic Leukemia (CLL)/ Small lymphocytic lymphoma (SLL)
MCL
FL
Marginal zone lymphoma

27

Described T-cell lymphomas morphologically

Heterogeneous population of small, medium-sized, and large neoplastic T cells

28

When does CD20 expressed ?

Appears later with the light chain rearrangement

29

What is useful in the diagnostic work-up of T-cell lymphomas?

CD3, CD2, CD 5, CD7 recognize virtually all mature T cells

30

What are their fertility preservation options?

Semen cryopreservation
IVF
Ovarian tissue cryopreservation
Ovarian locate cryopreservation
Oophoropexy