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Flashcards in CNS stimulants Deck (17)
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1

CNS stimulants - 11 drugs

Amphetamine. Dextroamphetamine
Methamphetamine
Lisdexamphetamine
Methylphenidate
Modafinil
Armodafinil
Atomozetine
Guanfacine
Clonidine
Phentermine

2

CNS stimulants - adverse effects

Cardiovascular incidence (high BP, MI).
Decreased growth and weight gain.
Potential for abuse.

3

Amphetamin and its derivatives - Clinical use

ADHD, narcolepsy, obstructive sleep apnea/hypopnea syndrome and shift work sleep disorder.
Methamphetamine: Also short-term treatment for exogenous obesity.
Lisdexamphetamine: ONLY ADHD.
Phentermine: only obesity

4

Amphetamine and its derivatives - MOA

Indirect-acting adrenergic agonist. Increases release of NE and dopamine from nerve terminals by entering via the reuptake transporter, reversing the transport mechanism and inhibiting further reuptake of catecholamines

5

Amphetamine derivatives - 4 drugs

Dextroamphetamine
Methamphetamine
Lisdexamphetamine
Phentermine

6

Methylphenidate - MOA

Increase levels of catecholamines in central and peripheral synapses and primarily inhibit dopamine reuptake

7

Methylphenidate - indications

ADHD

8

Comparison of adverse effects of the sympathomimetics and amphetamines

The sympathomimetics show less irritability, anxiety and anorexia than amphetamines

9

Sympathomimetic CNS stimulants - 3 drugs

Methylphenidate
Modafinil
Armodafinil

10

Modafinil, armodafinil - MOA

Increase levels of catecholamines in central and peripheral synapses and primarily inhibit dopamine reuptake

11

Modafinil, armodafinil - indications

Narcolepsy.
Obstructive sleep apnea/hypopnea syndrome.
Shift work sleep disorder.
Off-label for ADHD.

12

Atomoxetine - MOA

Norepinephrine reuptake inhibitor with some selectivity

13

Atomoxetine - Indications

ADHD

14

Guanfacine and clonidine - MOA

Alpha2-receptor agonists

15

Guanfacine and clonidine - indications

Hypertension, ADHD

16

Phentermine - MOA

Stimulates the satiety center in the hypothalamus through sympathomimetic activity

17

Phentermine compared to amphetamine

Lower dependence liability than amphetamine.