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Flashcards in CNS stimulants Deck (17)
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1
Q

CNS stimulants - 11 drugs

A
Amphetamine. Dextroamphetamine
Methamphetamine
Lisdexamphetamine 
Methylphenidate 
Modafinil
Armodafinil
Atomozetine
Guanfacine
Clonidine 
Phentermine
2
Q

CNS stimulants - adverse effects

A

Cardiovascular incidence (high BP, MI).
Decreased growth and weight gain.
Potential for abuse.

3
Q

Amphetamin and its derivatives - Clinical use

A

ADHD, narcolepsy, obstructive sleep apnea/hypopnea syndrome and shift work sleep disorder.
Methamphetamine: Also short-term treatment for exogenous obesity.
Lisdexamphetamine: ONLY ADHD.
Phentermine: only obesity

4
Q

Amphetamine and its derivatives - MOA

A

Indirect-acting adrenergic agonist. Increases release of NE and dopamine from nerve terminals by entering via the reuptake transporter, reversing the transport mechanism and inhibiting further reuptake of catecholamines

5
Q

Amphetamine derivatives - 4 drugs

A

Dextroamphetamine
Methamphetamine
Lisdexamphetamine
Phentermine

6
Q

Methylphenidate - MOA

A

Increase levels of catecholamines in central and peripheral synapses and primarily inhibit dopamine reuptake

7
Q

Methylphenidate - indications

A

ADHD

8
Q

Comparison of adverse effects of the sympathomimetics and amphetamines

A

The sympathomimetics show less irritability, anxiety and anorexia than amphetamines

9
Q

Sympathomimetic CNS stimulants - 3 drugs

A

Methylphenidate
Modafinil
Armodafinil

10
Q

Modafinil, armodafinil - MOA

A

Increase levels of catecholamines in central and peripheral synapses and primarily inhibit dopamine reuptake

11
Q

Modafinil, armodafinil - indications

A

Narcolepsy.
Obstructive sleep apnea/hypopnea syndrome.
Shift work sleep disorder.
Off-label for ADHD.

12
Q

Atomoxetine - MOA

A

Norepinephrine reuptake inhibitor with some selectivity

13
Q

Atomoxetine - Indications

A

ADHD

14
Q

Guanfacine and clonidine - MOA

A

Alpha2-receptor agonists

15
Q

Guanfacine and clonidine - indications

A

Hypertension, ADHD

16
Q

Phentermine - MOA

A

Stimulates the satiety center in the hypothalamus through sympathomimetic activity

17
Q

Phentermine compared to amphetamine

A

Lower dependence liability than amphetamine.