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22 Psychotherapeutic drugs > CNS stimulants > Flashcards

Flashcards in CNS stimulants Deck (17)
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1
Q
CNS stimulants - 11 drugs
A
Amphetamine. Dextroamphetamine
Methamphetamine
Lisdexamphetamine
Methylphenidate
Modafinil
Armodafinil
Atomozetine
Guanfacine
Clonidine
Phentermine
2
Q
CNS stimulants - adverse effects
A
Cardiovascular incidence (high BP, MI).
Decreased growth and weight gain.
Potential for abuse.
3
Q
Amphetamin and its derivatives - Clinical use
A
ADHD, narcolepsy, obstructive sleep apnea/hypopnea syndrome and shift work sleep disorder.
Methamphetamine: Also short-term treatment for exogenous obesity.
Lisdexamphetamine: ONLY ADHD.
Phentermine: only obesity
4
Q
Amphetamine and its derivatives - MOA
A
Indirect-acting adrenergic agonist. Increases release of NE and dopamine from nerve terminals by entering via the reuptake transporter, reversing the transport mechanism and inhibiting further reuptake of catecholamines
5
Q
Amphetamine derivatives - 4 drugs
A
Dextroamphetamine
Methamphetamine
Lisdexamphetamine
Phentermine
6
Q
Methylphenidate - MOA
A
Increase levels of catecholamines in central and peripheral synapses and primarily inhibit dopamine reuptake
7
Q
Methylphenidate - indications
A
ADHD
8
Q
Comparison of adverse effects of the sympathomimetics and amphetamines
A
The sympathomimetics show less irritability, anxiety and anorexia than amphetamines
9
Q
Sympathomimetic CNS stimulants - 3 drugs
A
Methylphenidate
Modafinil
Armodafinil
10
Q
Modafinil, armodafinil - MOA
A
Increase levels of catecholamines in central and peripheral synapses and primarily inhibit dopamine reuptake
11
Q
Modafinil, armodafinil - indications
A
Narcolepsy.
Obstructive sleep apnea/hypopnea syndrome.
Shift work sleep disorder.
Off-label for ADHD.
12
Q
Atomoxetine - MOA
A
Norepinephrine reuptake inhibitor with some selectivity
13
Q
Atomoxetine - Indications
A
ADHD
14
Q
Guanfacine and clonidine - MOA
A
Alpha2-receptor agonists
15
Q
Guanfacine and clonidine - indications
A
Hypertension, ADHD
16
Q
Phentermine - MOA
A
Stimulates the satiety center in the hypothalamus through sympathomimetic activity
17
Q
Phentermine compared to amphetamine
A
Lower dependence liability than amphetamine.