SNRIs + MAO inhibitors Flashcards Preview

22 Psychotherapeutic drugs > SNRIs + MAO inhibitors > Flashcards

Flashcards in SNRIs + MAO inhibitors Deck (18)
Loading flashcards...
1
Q
SNRIs - 4 drugs
A
Duloxetine
Venlafaxine
Desvenlafaxine
Milnacipran
2
Q
SNRIs - MOA
A
Selective for SER and NE, but do not activate many other receptors
3
Q
SNRIs - Indications
A
Depression, eating disorders (bulimia and anorexia nervosa), anxiety disorders (panic disorder, phobic disorders, OCD).
Also effective for: fibromyalgia, autism, premenstrual dysphoric disorder
4
Q
Duloxetine - indications
A
Major depressive disorder.
Diabetic peripheral neuropathic pain.
Generalized anxiety disorders.
Fibromyalgia.
5
Q
Venlafaxine, desvenlafaxine - MOA
A
Strongly inhibit reuptake of both norepinephrine and serotonin. Do not antagonize muscarinic, adrenergic or histamine receptors
6
Q
Venlafaxine, desvenlafaxine - Adverse effects
A
Similar to adverse effects of SSRIs.
Few autonomic, sedative or cardiovascular side effects
7
Q
Milnacipran - indications
A
ONLY fibromyalgia
8
Q
MAOIs - 5 drugs
A
Isocarboxazid
Phenelzine
Tranylcypromine
Moclobemide
Selegiline
9
Q
Difference between MAO-A and MAO-B
A
Inhibition of MAO-A stops oxidation of mainly serotonin (some NE and dopamine as well).
Inhibition of MAO-B stops oxidation of dopamine.
Therapeutic effects of MAOIs are mainly from inhibition of MAO-A (except for the selective MAO-B inhibitors)
10
Q
MAOIs - indications
A
Treatment-resistant depression
11
Q
What should be avoided when taking MAOIs?
A
SSRIs (serotonin syndrome).
Sympathomimetics, TCAs.
Aged cheeses, beer, wines, meats and fish, rasins, broad beans, avocados, canned figs, choclate and coffie
12
Q
MAOIs - adverse effects
A
Serotonin syndrome (agitation, restlessness, confusion, insomnia, seizures, severe hypertension, GI symptoms).
Hypertensive crisis (occipital headache, palpitation, neck stiffness, soreness, nausea, vomiting, sweating, photophobia)
13
Q
1st generation MAOIs
A
Isocarboxazid
Phenelzine
Tranylcypromine
14
Q
2nd generation MAOIs
A
Moclobemide (RIMA - reversible inhibitor of MAO-A)
15
Q
Selevtive MAO-B inhibitor
A
Selegiline
16
Q
1st generation MAOIs - MOA
A
All: Bind irreversibly and inhibit MAO-A and MOA-B.
Phenelzine and tranylcyrpomide: Inhibit SER more than NE, antidepressant effect from down-regulation of presynaptic autoreceptors and increased firing of serotonergic neurons
17
Q
Moclobemide - indications
A
Depression
18
Q
Selegiline - indications
A
Parkinson disease
Depression