Typical (1st generation) antipsychotics Flashcards Preview

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Flashcards in Typical (1st generation) antipsychotics Deck (14)
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1
Q
Typical antipsychotics - 7 drugs
A
Chlorpromazine
Fluphenazine
Thioridazine
Haloperidol
Trifluoperazine
Thiothixene
Loxapine
2
Q
Typical antipsychotics - MOA
A
Blockade of D2 receptors in mesolimbic pathway represses positive symptoms within 1-3 weeks. Blockade of D2 receptors in basal ganglia cause adverse effects.
3
Q
Typical antipsychotics - adverse effects caused by D2 blockade
A
Tuberoinfundibular pathway: Increased prolactin levels, gynecomastia, menstrual irregularities.
EPSs:
1. Akathisia
2. Psuedoparkinsonism
3. Dystonias: oculogyric crisis, glossospasm, tongue protrusion, torticollis, life-threatening pharyngeal dystonias
4
Q
Typical antipsychotics - adverse effects caused by supersensitivity and effect on hypothalamus
A
Supersensitivity: Tardive dyskinesia - Abnormal facial movements, abnormal limb and truncal movements.
Hypothalamus: Poikilothermy, heat stroke, hypo- and hyperthermia.
5
Q
Potency of the different typical antipsychotics
A
Low potency: Chlorpromazine, thioridazine.
Medium potency: Loxapine.
High potency: Fluphenazine, haloperidol, trifluoperazine, thiothixene.
6
Q
Thioridazine - adverse effects
A
Pigmentary retinopathy and cardiac toxicity (high doses). Fewer EPSs.
Greater anticholinergic effect.
Poikilothermy.
7
Q
Haloperidol - indications
A
Schizophrenia
Tourette syndrome
8
Q
Typical antipsychotics - general interactions
A
Additive effects with antiadrenergic, anticholinergic, CNS depressants. Betablockers and antidepressants may increase levels of both drugs.
9
Q
Which typical antipsychotics may decrease the levels of lithium?
A
Chlorpromazine
Thioridazine
Trifluoperazine
10
Q
Typical antipsychotics with more EPSs
A
Fluphenazine
Haloperidol
11
Q
Haloperidol - interactions
A
Barbiturates and carbamazepine decrease serum levels.
Quinidine increases serum levels
12
Q
Typical antipsychotics with fewer autonomic effects
A
Fluphenaizne
13
Q
Typical antipsychotic with a greater anticholinergic effect
A
Thioridazine
14
Q
Administration of antipsychotics
A
Chlorpromazine: Oral, IM, IV
Fluphenazine: Oral, IM
Thioridazine: Oral
Haloperidol: Oral, IM
Trifluoperazine: Oral, IM
Thiothixene: Oral, IM
Loxapine: Oral, IM