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Flashcards in Typical (1st generation) antipsychotics Deck (14)
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1

Typical antipsychotics - 7 drugs

Chlorpromazine
Fluphenazine
Thioridazine
Haloperidol
Trifluoperazine
Thiothixene
Loxapine

2

Typical antipsychotics - MOA

Blockade of D2 receptors in mesolimbic pathway represses positive symptoms within 1-3 weeks. Blockade of D2 receptors in basal ganglia cause adverse effects.

3

Typical antipsychotics - adverse effects caused by D2 blockade

Tuberoinfundibular pathway: Increased prolactin levels, gynecomastia, menstrual irregularities.
EPSs:
1. Akathisia
2. Psuedoparkinsonism
3. Dystonias: oculogyric crisis, glossospasm, tongue protrusion, torticollis, life-threatening pharyngeal dystonias

4

Typical antipsychotics - adverse effects caused by supersensitivity and effect on hypothalamus

Supersensitivity: Tardive dyskinesia - Abnormal facial movements, abnormal limb and truncal movements.
Hypothalamus: Poikilothermy, heat stroke, hypo- and hyperthermia.

5

Potency of the different typical antipsychotics

Low potency: Chlorpromazine, thioridazine.
Medium potency: Loxapine.
High potency: Fluphenazine, haloperidol, trifluoperazine, thiothixene.

6

Thioridazine - adverse effects

Pigmentary retinopathy and cardiac toxicity (high doses). Fewer EPSs.
Greater anticholinergic effect.
Poikilothermy.

7

Haloperidol - indications

Schizophrenia
Tourette syndrome

8

Typical antipsychotics - general interactions

Additive effects with antiadrenergic, anticholinergic, CNS depressants. Betablockers and antidepressants may increase levels of both drugs.

9

Which typical antipsychotics may decrease the levels of lithium?

Chlorpromazine
Thioridazine
Trifluoperazine

10

Typical antipsychotics with more EPSs

Fluphenazine
Haloperidol

11

Haloperidol - interactions

Barbiturates and carbamazepine decrease serum levels.
Quinidine increases serum levels

12

Typical antipsychotics with fewer autonomic effects

Fluphenaizne

13

Typical antipsychotic with a greater anticholinergic effect

Thioridazine

14

Administration of antipsychotics

Chlorpromazine: Oral, IM, IV
Fluphenazine: Oral, IM
Thioridazine: Oral
Haloperidol: Oral, IM
Trifluoperazine: Oral, IM
Thiothixene: Oral, IM
Loxapine: Oral, IM