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22 Psychotherapeutic drugs > Other antidepressants > Flashcards

Flashcards in Other antidepressants Deck (16)
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1
Q
Other antidepressants - 5 drugs
A
Bupropion
Mirtazapine
Trazodone
Vilazodone
Hypericin
2
Q
Bupropion - MOA
A
Weak inhibitor of neuronal reuptake of DOP, NOR, SER at their transporters DAT, NET, SERT.
Noncompetative antagonist at nicotinic cholinergic receptors
3
Q
Bupropion - indications
A
Adjunct therapy for smoking cessation
4
Q
Bupropion - adverse effects
A
Agitation, insomnia, nausea, weight loss
5
Q
Mirtazapine - MOA
A
Antidepressant and antianxiety effects. Blocks presynaptic alpha2-adrenergic autoreceptors and heteroreceptors, causing increased neuronal release of NE and SER respectively. Increases NE levels more than TCAs.
Potent antagonist of 5-HT2 and 5-HT3 receptors.
6
Q
Mirtazapine - adverse effects
A
Agranulocytosis.
Significant elevation of hepatic enzyme levels
7
Q
Trazodone - MOA
A
Selectively inhibits the neuronal reuptake of serotonin.
Antagonist at 5-HT2A receptors
8
Q
Trazodone - adverse effects
A
Considerable sedation and orthostatic hypotension
9
Q
Vilazodone - MOA
A
Selectively inhibits neuronal reuptake of serotonin. Also partial agonist of 5-HT1A receptors (accounting for anxiolytic effect). Enhancement of serotonergic activity in CNS
10
Q
Tetracyclic antidepressant (TeCA)
A
Mirtazapine
11
Q
Mood stabilizers - 3 drugs
A
Lithium
Carbamazepine
Valproate
12
Q
Lithium - Indications
A
Manic phase of bipolar disorder
13
Q
Lithium - MOA
A
Reduces both manic and depressive symptoms, but greater activity for manic phase. Suppresses the formation of second messengers involved in SER and NE neurotransmission. Reduces formation of IP3 by inhibiting myo-inositol-1-phosphatase. Interferes with formation of cAMP. Maximal response after days/weeks.
14
Q
Lithium - adverse effects
A
Neurotoxicity, cardiac toxicity (dysrhythmias). Nausea and vomiting are the earliest signs of overdose.
At therapeutic dose: drowsiness, weight gain, fine hand tremor, polyuria. Hypothyroidism.
15
Q
Lithium - interactions
A
Renal lithium clearance increases during pregnancy.
Sodium competes with lithium for tubular reabsorption increased excretion of lithium.
NSAIDs and diuretics increase serum levels.
16
Q
Valproate - indications as mood stabilizer
A
Rapidly cycling of manic and depressive episodes & pts with coexisting substance abuse