SSRIs Flashcards Preview

22 Psychotherapeutic drugs > SSRIs > Flashcards

Flashcards in SSRIs Deck (15)
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1
Q

SSRIs - 6 drugs

A
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
Citalopram
Escitalopram
2
Q

SSRIs - MOA

A

Selectively block neuronal reuptake of SER, much less effect on NE reuptake than TCAs

3
Q

Administration of SSRIs

A

In the morning (tend to increase alertness)

4
Q

SSRIs - contraindications

A

Caution in seizure disorders, hepatic disorders, diabetes and bipolar disorder.
Should not be given with MAOIs or triptan agents (serotonin syndrome).

5
Q

Serotonin syndrome - symptoms

A
Agitation
Restlessness
Insomnia
Confusion
Seizures
Severe hypertension
GI symptoms
6
Q

SSRIs - adverse effects

A

Nervousness, dizziness, insomnia. Male sexual dysfunction (priapism, impotence)

7
Q

SSRIs - interactions

A

SSRIs increase serum levels of antipsychotic drugs, TCAs, dextromethorphan, alprazolam, diazepam, carbamazepine, phenytoin, others.
Increase hypoptothrombinemic effect of warfarin.

8
Q

Which SSRI is long acting?

A

Fluoxetine

9
Q

Which SSRI has more and which has less interactions than other SSRIs

A

More interactions: Fluoxetine.

Less interactions: sertraline.

10
Q

Fluoxetine - adverse effects

A

SIADH

DIA: Impair regulation of blood glucose

11
Q

Fluvoxamine - indications

A

OCD
Depression
Panic disorder

12
Q

More sedating SSRIs

A

Fluvoxamine

Paroxetine

13
Q

Citalopram - adverse effects

A

Increase of QT interval and torsade de pointes

14
Q

SSRI preferred in elderly

A

Sertaline

15
Q

Clinical use of SSRIs

A

Depression
Eating disorders (bulimia and anorexia nervosa)
Anxiety disorders (panic disorder, phobic disorders, OCD).
Also effective for: fibromyalgia, autism, premenstrual dysphoric disorder.