SSRIs Flashcards Preview

22 Psychotherapeutic drugs > SSRIs > Flashcards

Flashcards in SSRIs Deck (15)
Loading flashcards...
1

SSRIs - 6 drugs

Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
Citalopram
Escitalopram

2

SSRIs - MOA

Selectively block neuronal reuptake of SER, much less effect on NE reuptake than TCAs

3

Administration of SSRIs

In the morning (tend to increase alertness)

4

SSRIs - contraindications

Caution in seizure disorders, hepatic disorders, diabetes and bipolar disorder.
Should not be given with MAOIs or triptan agents (serotonin syndrome).

5

Serotonin syndrome - symptoms

Agitation
Restlessness
Insomnia
Confusion
Seizures
Severe hypertension
GI symptoms

6

SSRIs - adverse effects

Nervousness, dizziness, insomnia. Male sexual dysfunction (priapism, impotence)

7

SSRIs - interactions

SSRIs increase serum levels of antipsychotic drugs, TCAs, dextromethorphan, alprazolam, diazepam, carbamazepine, phenytoin, others.
Increase hypoptothrombinemic effect of warfarin.

8

Which SSRI is long acting?

Fluoxetine

9

Which SSRI has more and which has less interactions than other SSRIs

More interactions: Fluoxetine.
Less interactions: sertraline.

10

Fluoxetine - adverse effects

SIADH
DIA: Impair regulation of blood glucose

11

Fluvoxamine - indications

OCD
Depression
Panic disorder

12

More sedating SSRIs

Fluvoxamine
Paroxetine

13

Citalopram - adverse effects

Increase of QT interval and torsade de pointes

14

SSRI preferred in elderly

Sertaline

15

Clinical use of SSRIs

Depression
Eating disorders (bulimia and anorexia nervosa)
Anxiety disorders (panic disorder, phobic disorders, OCD).
Also effective for: fibromyalgia, autism, premenstrual dysphoric disorder.