Components of innate immunity Flashcards
(17 cards)
3 components of innate immunity
Circulating effector cells
Circulating effector proteins
Cytokines
3 types of circulating effector cells
Neutrophils, Macrophages, NK cells
Function of Neutrophils
Early phagocytosis and killing of microbes
Function of Macrophages
Efficient phagocytosis and killing of microbes, and SECRETION OF CYTOKINES that stimulate inflammation
Function of NK cells
Lysis of infected cells, ACTIVATION OF MACROPHAGES
3 types of Circulating effector proteins
Complement
Mannose-binding (collection)
C-reactive protein (pentraxin)
Functions of complement
Killing of microbes, opsonization of microbes, ACTIVATION OF LEUKOCYTES
Function of Mannose-binding (collection)
Opsonization of microbes, ACTIVATION OF COMPLEMENT (LECTIN PATHWAY)
C-reactive protein (Pentraxin functions
opsonization of microbes, ACTIVATION OF COMPLEMENT
6 types of Cytokines
- TNF, IL-1, chemokines
- IFN-alpha, -beta
- IFN-gamma
- IL-12
- IL-15
- IL-10, TGF-beta
Function of TNF, IL-1, chemokines
inflammation
Function of IFN-alpha, -beta
resistance to viral infection
Function of IFN-Gamma
Macrophage activation
Function of IL-12
IFN-gamm production by NK cells and T cells
Function of IL-15
Proliferation of NK cells
IL-10, TGF-beta functions
Control of inflammation
opsonization is ________
The process by which a pathogen is marked for elimination