Components of innate immunity Flashcards

(17 cards)

1
Q

3 components of innate immunity

A

Circulating effector cells
Circulating effector proteins
Cytokines

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2
Q

3 types of circulating effector cells

A

Neutrophils, Macrophages, NK cells

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3
Q

Function of Neutrophils

A

Early phagocytosis and killing of microbes

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4
Q

Function of Macrophages

A

Efficient phagocytosis and killing of microbes, and SECRETION OF CYTOKINES that stimulate inflammation

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5
Q

Function of NK cells

A

Lysis of infected cells, ACTIVATION OF MACROPHAGES

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6
Q

3 types of Circulating effector proteins

A

Complement
Mannose-binding (collection)
C-reactive protein (pentraxin)

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7
Q

Functions of complement

A

Killing of microbes, opsonization of microbes, ACTIVATION OF LEUKOCYTES

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8
Q

Function of Mannose-binding (collection)

A

Opsonization of microbes, ACTIVATION OF COMPLEMENT (LECTIN PATHWAY)

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9
Q

C-reactive protein (Pentraxin functions

A

opsonization of microbes, ACTIVATION OF COMPLEMENT

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10
Q

6 types of Cytokines

A
  1. TNF, IL-1, chemokines
  2. IFN-alpha, -beta
  3. IFN-gamma
  4. IL-12
  5. IL-15
  6. IL-10, TGF-beta
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11
Q

Function of TNF, IL-1, chemokines

A

inflammation

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12
Q

Function of IFN-alpha, -beta

A

resistance to viral infection

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13
Q

Function of IFN-Gamma

A

Macrophage activation

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14
Q

Function of IL-12

A

IFN-gamm production by NK cells and T cells

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15
Q

Function of IL-15

A

Proliferation of NK cells

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16
Q

IL-10, TGF-beta functions

A

Control of inflammation

17
Q

opsonization is ________

A

The process by which a pathogen is marked for elimination