Immunogenetics Flashcards
(16 cards)
In MHC I molecules differences among individuals occur in which 2 domains?
Alpha 1 & alpha 2
What is special about alpha 3 region on MHC I molecules?
invariant
alpha 3 invariant binds to which cluster of differentiation marker?
CD8+
What does B2m do?
Helps maintain conformation
Most variability occurs in which region?
a1/a2
MHC I binding binds how many amino acids?
8-10
Which MHC I genes are the most polymorphic?
HLA-A,B,&C
Which chromosome is the HLA on?
Chromosome 6p21.3
two-one point three, not twenty one
What is a haplotype?
a set of genes that determine different antigens, but are closely linked an inherited together.
What is another definition of haplotype
Observed patterns of various combinations of alleles for genes
In MHC II molecules where is the variable region?
alpha 1 and beta 1 domains
The part that looks like the stingray
Why should I care about the variable region?
That is where differences can occur in individuals
CD4+ binds where in an MHC II molecule?
Beta-2 domain
How many amino acids does MHC II bind?
13-25
MHC II molecules can bind any only certain peptides? T or F
True
Most Important Class II MHC genes
HLA- DP, DQ, DR
