Innate Immunity Flashcards
(9 cards)
1
Q
Neutrophil activation leads to
A
respiratory bursts and release of granules to control bacterial growth
2
Q
Neutrophils are the first to
A
arrive at the site of tissue damage
3
Q
Macrophages do what two things
A
engulf organisms and release inflammatory mediators
4
Q
Eosinophils contain what
A
cationic granule proteins
5
Q
Eosinophils fight what?
A
helminthes and other multicellular parasites
6
Q
NK cells kill what and how?
A
infected host cells, using perforin
7
Q
Inflammation activated endothelial cells increase expression of 2 adhesion molecules, what are they
A
E-selectin and P selectin
8
Q
Neutrophils ______ly express ligands for ES and PS.
A
constitutively
9
Q
4 steps of Neutrophil action
A
- Neutrophils slow down and roll along the endothelium
- Tight binding between integrins(leukocytes) and integrin ligands(endothelial cells)
- Diapedesis - transmigration through endothelium
- IL-8 (chemoattractant) controls migration of neutrophils into inflammatory sites.
