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Flashcards in Connective tissue Deck (29)
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0

What is larger sulfated GAGs or non-sulfated GAGs

non-sulfated

1

True or false; non-sulfated GAGs holds a lot of water

true

2

Which type of collagen makes up ~90% of total body collagen

type 1

3

True or false; collagen 1 is known for great tensile strength and stretching capabilities

false; does have great tensile strength but doesn't stretch

4

What vitamin is crucial for collagen formation?

Vitamin C - not enough = scurvy

5

True or false; elastic which can stretch 150% of resting length decreases as we age

true

6

Marfan's syndrome is an hereditary condition effecting what kind of ct?

elastic fibers

7

What kind of ct is the same as collagen 3

reticular

8

True or false; reticular fibers which typically last ~3 days are not affected by aging

true

9

What is the first fiber produced during wound healing

reticular

10

What are fibroblast typically derived from? When would they divide?

from mesenchyme cells

primarily during wound healing

11

What is the structural purpose of fibroblasts

produce and maintain matrix

12

What is the purpose of fibroblast in healing?

Produce growth factors and scar formation

13

True or false; fibroblast have some defensive function

true - produce cytokines and enzymes - can phagocytize is needed

14

What is a mature less active fibroblast? What can it produce?

fibrocyte

hyloronic acid, ground substance, reticular fibers

15

What possesses features of fibroblasts in smooth muscle

myofibroblasts

16

True or false; adipocytes function in lipid storage and produce leptin

true

17

True or false; plasma cells are typically found in the blood

false

18

What are macrophages derived from?

monocytes

19

Large cells with an indented or kidney bean shaped nucleus often containing residual bodies in cytoplasm best describes what?

macrophages

20

True or false; on top of phagocytizing macrophages act as APCs and create foreign body giant cells

true

21

What is a foreign body giant cell

permanent fusion of many macrophages

22

Mast cells - which are large cells containing cytoplasmic granules are derived from what?

a bone marrow precursor

23

True or false; histamine increases permeability - increases blood flow (vasodilation) and contracts smooth muscle

true

24

What is heparin? What is its effect?

Primary mediator of inflammation in an allergic reaction

switches off histamine by binding to it

25

What is an ECF? What do they do?

Eosinophil chemotactic factor

attracts eosinophils

26

What do eosinophils do? What attracts them?

inhibit leukotrienes - inhibit mast cell degranulation - limit the effects of histamine and leukotrienes

ECF (eosinophil chemotactic factor)

27

What are NCFs? What do they attract?

neutrophil chemotactic factor

attracts neutrophils

28

What effect does leukotriene have?

Same as histamine - but much more powerful (1000x) - will also extend and amplify histamine's effects