Connective tissue

Question 0

True or false; non-sulfated GAGs holds a lot of water

Answer 0

true

Question 1

What is larger sulfated GAGs or non-sulfated GAGs

Answer 1

non-sulfated

Question 2

Which type of collagen makes up ~90% of total body collagen

Answer 2

type 1

Question 3

True or false; collagen 1 is known for great tensile strength and stretching capabilities

Answer 3

false; does have great tensile strength but doesn’t stretch

Question 4

What vitamin is crucial for collagen formation?

Answer 4

Vitamin C - not enough = scurvy

Question 5

True or false; elastic which can stretch 150% of resting length decreases as we age

Answer 5

true

Question 6

Marfan’s syndrome is an hereditary condition effecting what kind of ct?

Answer 6

elastic fibers

Question 7

What kind of ct is the same as collagen 3

Answer 7

reticular

Question 8

True or false; reticular fibers which typically last ~3 days are not affected by aging

Answer 8

true

Question 9

What is the first fiber produced during wound healing

Answer 9

reticular

Question 10

What are fibroblast typically derived from? When would they divide?

Answer 10

from mesenchyme cells

primarily during wound healing

Question 11

What is the structural purpose of fibroblasts

Answer 11

produce and maintain matrix

Question 12

What is the purpose of fibroblast in healing?

Answer 12

Produce growth factors and scar formation

Question 13

True or false; fibroblast have some defensive function

Answer 13

true - produce cytokines and enzymes - can phagocytize is needed

Question 14

What is a mature less active fibroblast? What can it produce?

Answer 14

fibrocyte

hyloronic acid, ground substance, reticular fibers

Question 15

What possesses features of fibroblasts in smooth muscle

Answer 15

myofibroblasts

Question 16

True or false; adipocytes function in lipid storage and produce leptin

Answer 16

true

Question 17

True or false; plasma cells are typically found in the blood

Answer 17

false

Question 18

What are macrophages derived from?

Answer 18

monocytes

Question 19

Large cells with an indented or kidney bean shaped nucleus often containing residual bodies in cytoplasm best describes what?

Answer 19

macrophages

Question 20

True or false; on top of phagocytizing macrophages act as APCs and create foreign body giant cells

Answer 20

true

Question 21

What is a foreign body giant cell

Answer 21

permanent fusion of many macrophages

Question 22

Mast cells - which are large cells containing cytoplasmic granules are derived from what?

Answer 22

a bone marrow precursor

Question 23

True or false; histamine increases permeability - increases blood flow (vasodilation) and contracts smooth muscle

Answer 23

true

Question 24

What is heparin? What is its effect?

Answer 24

Primary mediator of inflammation in an allergic reaction switches off histamine by binding to it

Question 25

What is an ECF? What do they do?

Answer 25

Eosinophil chemotactic factor attracts eosinophils

Question 26

What do eosinophils do? What attracts them?

Answer 26

inhibit leukotrienes - inhibit mast cell degranulation - limit the effects of histamine and leukotrienes ECF (eosinophil chemotactic factor)

Question 27

What are NCFs? What do they attract?

Answer 27

neutrophil chemotactic factor attracts neutrophils

Question 28

What effect does leukotriene have?

Answer 28

Same as histamine - but much more powerful (1000x) - will also extend and amplify histamine's effects