Flashcards in connective tissue Deck (21)
define connective tissue
a tissue that connects, supports, binds or separates other tissues and organs, mesodermally derived, made up of cells, extracellular fibres and ground substance
what are fibroblasts
secrete ground substance and fibres
what are macrophages
phagocytosis and antigen presenting cells
what are mast cells
granules which contain histamine
what are mesenchymal cells in connective tissue?
undifferentiated - to maintain extracellular matrix
what is ground substance?
hyaluronate proteoglycan aggregates with gag units that attract water
what are the function of collagen fibres within connective tissue
interweave proteoglycan monomers
what is the function of elastic fibres in connectie tissue
allow stretch due to lysine
describe loose connective tissue
forms a framework around structures
high ratio of ground substance in which all structures lie
e.g. areolar, reticular, adipose
describe regular dense connective tissue
closely packed fibres that run uni-directionally to give good tensile strength e.g. tendons
describe irregular connective tissue
closely packed fibres tht run multi-directionally for multidirectional force resistance e.g.dermis
what is marphans syndrome?
utation in fibrillin gene - disorder of elastin - tissue irregularity
what is ehlers-danlos?
consequence of collagen abnormalaties of dermis and tendons - joint dislocations and skin deformation
what is systematic sclerosis
excessive collagen in organs, causes hardening and functional impairment
what is the function of elastic fibres?
alveolar walls maintain shape ad protection during distersion
what is the function of reticular fibres?
form a structural framework around organs e.g. liver
what is the function of mucous connective tissue?
component cells - large stellate fibroblasts which fuse with adjacent cells
loose amorphous connective tissue with jelly like matrix formed from hykaronic acid sparsly populated type 1 and 3 collagen fibres and fibroblasts
describe aerolar connective tissue
formed by differentiation of cells from the mesochyme
loosly aranged fibroelastic connective tissue
stretch as just uner skin
forms submucosa beneath epithelia of mm
contains fibroblasts, macrophages and mast cels
collagen fibres and elastin for branching network
describe adipose tissue
cells between llagen fibres
unstained as fat dissolves during processing
insulation and shock absorber
can generate heat
describe the dermis
immediately below the epidermis
thick layer of onnective tissue containing blood vessels,lymphatics, skin eppendages sensory nerves and nerve endings
inly thick collagen fibres
variable amount of elastic fibres