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Flashcards in connective tissue Deck (21)
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define connective tissue

a tissue that connects, supports, binds or separates other tissues and organs, mesodermally derived, made up of cells, extracellular fibres and ground substance

1

what are fibroblasts

secrete ground substance and fibres

2

what are macrophages

phagocytosis and antigen presenting cells

3

what are mast cells

granules which contain histamine

4

what are mesenchymal cells in connective tissue?

undifferentiated - to maintain extracellular matrix

5

what is ground substance?

hyaluronate proteoglycan aggregates with gag units that attract water

6

what are the function of collagen fibres within connective tissue

interweave proteoglycan monomers

7

what is the function of elastic fibres in connectie tissue

allow stretch due to lysine

8

describe loose connective tissue

forms a framework around structures
high ratio of ground substance in which all structures lie
e.g. areolar, reticular, adipose

9

describe regular dense connective tissue

closely packed fibres that run uni-directionally to give good tensile strength e.g. tendons

10

describe irregular connective tissue

closely packed fibres tht run multi-directionally for multidirectional force resistance e.g.dermis

11

what is marphans syndrome?

utation in fibrillin gene - disorder of elastin - tissue irregularity

12

what is ehlers-danlos?

consequence of collagen abnormalaties of dermis and tendons - joint dislocations and skin deformation

13

what is systematic sclerosis

excessive collagen in organs, causes hardening and functional impairment

14

what is the function of elastic fibres?

alveolar walls maintain shape ad protection during distersion

15

what is the function of reticular fibres?

form a structural framework around organs e.g. liver

16

what is the function of mucous connective tissue?

in umbilical
component cells - large stellate fibroblasts which fuse with adjacent cells
loose amorphous connective tissue with jelly like matrix formed from hykaronic acid sparsly populated type 1 and 3 collagen fibres and fibroblasts

17

describe aerolar connective tissue

formed by differentiation of cells from the mesochyme
loosly aranged fibroelastic connective tissue
stretch as just uner skin
forms submucosa beneath epithelia of mm
contains fibroblasts, macrophages and mast cels
collagen fibres and elastin for branching network

18

describe adipose tissue

cells between llagen fibres
unstained as fat dissolves during processing
insulation and shock absorber
can generate heat

19

describe the dermis

immediately below the epidermis
thick layer of onnective tissue containing blood vessels,lymphatics, skin eppendages sensory nerves and nerve endings
inly thick collagen fibres
variable amount of elastic fibres

20

describe tendons

connect muscle to bone
parallel bunches of collaen
interspersed with rows of flattened fibroblasts
groups of collagen fibres and fibroblasts form fasicles
fasicles seperated by loose connective tissuegroups of fasicles held together by peritndioum
fibrous sheath surrounds the whole tendon