Connective tissue diseases Flashcards Preview

Pathology > Connective tissue diseases > Flashcards

Flashcards in Connective tissue diseases Deck (10):
1

SLE - features (8)

4/11 ACR criteria - SOAP BRAIN MD

  • Serositis - pleruritic chest pain (plerual inflammation)
  • oral ulcers
  • arthritis
  • photosensitivity
  • Blood disorders - pancytopenia
  • renal involvement
  • ANA +ve
  • Immune path - anti DsDNA, anti-smith, anti-histones
  • Neuro symptoms
  • Malar - butterfly rash
  • Discoid rash 

2

ANA ab in SLE - specificly what can the abs be? (3)

  1. Anti Ds DNA
  2. Anti-smith - most specific but only 30% pts have
  3. Anti-histone - drug related e.g. hydralazine

3

What happens to glomerulus in SLE?

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Immune complex deposition results in thickened GBM - membranous GNpathy

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4

What is this?

 

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Libman Sacks endocarditis - strands of fibrin, neutrophils,lymphocytes (but no bacteria)

5

SLE: gender, ethnicity, HLA assc. 

Autoimmune multisystem disorder, high incidence in those with complement def, can be drug induced. F> M, afroC. 

HLA DR2/3 assc.

 

6

Scleroderma 'hard skin'. 

Features (5)

Scleroderma also autoimmune disorder, get tight skin due to excess collagen deposition & fibrosis

F -

  • Calcinosis - painful lesions on tips of fingers
  • Raynauds - triphasic colour change
  • Esophageal dysmotility - also due to collagen deposition
  • Sclerodactyl - tightening of skin of fingers (cant pull it)
  • Telangectasia

7

Scleroderma: can be diffuse or limited - what are the differences (abs & distribution)

What is the pattern of immunofluorescence

  • Diffuse - involves trunk, anti DNA topoisomerase (Scl70)
  • limited form - anticentromere ab

 

nucleolar pattern of IF

8

What will histology of Scleroderma show? (2)

  • Collagen excess deposition everywhere
  • onion skin thickening of arterioles - intimal thickening, present with renal crises - BP>200

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9

Mixed connective tissue disorder has features of 4 disorders, what are they?

  • SLE
  • Scleroderma
  • Dermatomyositis
  • Polymyositis

(myositis presents with prox muscle weakness & tenderness > raised CK)

10

Features of dermatomyositis (2)

  • Heliotrope rash
  • Gottron papules - erythematous rash over knuckles

 

Mixed connective tissue disorders have speckled ANA pattern

AntiJo-1 ab 

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