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CVPR: Pulmonary > Control of Respiration > Flashcards

Flashcards in Control of Respiration Deck (7)
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1

Inputs into the medulla

-peripheral chemoreceptors: located @ carotid bodies
-central chemorecptors: located on ventral surface of medulla

2

Respiratory center of brain

medulla

3

Types of peripheral chemoreceptors

1. increases ventilation in response to low arterial O2
2. increases ventilation in response to high arterial PCO2 ==> fast, seconds
3. increases ventilation in response to high arterial [H+] ==> fast, only mediator of response to metabolic acid-base insults

4

Properties of central chemoreceptors

-located @ medulla
-bind protons in CSF, but sense arterial CO2
-response is slow (minutes)
-mediates 80% of ventialtory response to high PaCO2 under long-term conditions

5

Integrated response to high altitude (short-term)

-decrease PIO2 ==> decrease PaO2 ==> increased activation of peripheral O2 receptors ==> increased ventilation ==> increased PaO2
-increased Va ==> decreased PaCO2 ==> decreased activation of central proton receptors ==> some suppression of increased Va ==> initial recovery of PaO2 is incomplete
-compensation occurs over 2-3 days ==> normal PaO2

6

Acclimatization to high altitude

-decreased PaCO2 ==> increased pH/alkalosis = respiratory alkalosis
-compensation: decreased bicarb reabsorption ==> decreased in pH ==> more H+ ==> increased central H+ receptor activation/removal of suppression of ventilation

7

Increased ventilation during exercise

-initially stimulated by increased CO2 consumption
-as Vo2 consumption increases, protons also contribute to increased stimulation