Control of Testicular function and sperm function and sperm physiology Flashcards Preview

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Flashcards in Control of Testicular function and sperm function and sperm physiology Deck (24)
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1

two functions of testicles

produce sperm and produce androgens and secrete

2

describe the anatomy of the testicles

divided into lobules which contain semineferous tubules and leydig cells, seminiferous tubules collect inot epididymis and join vas deferens

3

what celles are in seminiferous tubules

sertoli and spermatogonial cells

4

what does sertoli cell do

Support spermatogonial cells devolopment by,

Nutrition
Protection
Secretory
Excretory
 Provide structural support
 Create 2 compartments Create
2 compartments
 Provide nutrients
for mature sperm
 Eliminate degenerate Eliminate degenerate germ cells
 S t I hibi ABP Secre
tes Inhibin, ABP,
AMH and growth factors

5

when does spermatogenis start

Starts at puberty

6

how long does spermatogenisis cycle take

72 days

7

appreciate the stages of growth of perm cell

primary spermatome, early spermatid, late spermatid

8

in spermatogenesis what occurs first mitosis or meiosis

 Mitosis followed by Meiosis

9

what is spermiogensis

repacking of sperm, lose cholesterol, extension form traverse centriole,

10

what are the three parts of a mature sperm

tail piece, mid piece and head

11

what is the significance of the sertoli cell and junctional complex

they maintain a barrier between lumen and interstitial compartment. this is important so immune system can't attack foreign sperm cells

12

What does leydig cell do

Secrete androgens (C19), mainly
testosterone

13

how do leydig and sprematogonial sertoli cells interact

testosterone produced by leydig cells allow maturation of sperm by stimulating sertoli cells

14

what does fsh activate in testicles

sertoli cells

15

what does lh activate in testicles

leydig cells

16

what is role of prolactin in spermatogenisis

produced
by anterior
or
pituitary
and has a
facilitatory
action

17

what is sperm capacitation

Switching on” of sperm - HYPERACTIVE
 Takes about 4 hours after ejaculation Takes about
4 hours after ejaculation
 Cholesterol loss and calcium influx

18

outline sperm transport to egg

Ejaculation: deposition
of sperm in vagina
( ) acidic
)
 Cervix: Mucous barrier
and crypts act as sperm and crypts act as sperm
reservoirs - motility is
important
 Uterus and tubes: mild
contraction to propel the
sperm towards egg sperm towards egg
 Ampullary portion of the
tube: Fertilisation

19

what enzymes are in acrosome

Leads to exposure
of hyaluronidase of hyaluronidase
and acrosin
enzymes

20

outline acosome reaction at egg

Triggered by contact
with oocyte
 Interaction with ZP3
protein on oocyte
membrane
 Leads to exposure
of hyaluronidase of hyaluronidase
and acrosin
enzymes
 Facilitates oocyte
penetration

21

what occurs during oocyte activation

Release of cortical granules - block to
polyspermic penetration polyspermic penetration
 Resumption of meiosis
 Formation of the male and female
p( )

22

what effects sperm production

recreational anabolic abuse, no sperm. infection, vasectomy, enviroment, heat exposure to hot, radiation, alcohol and smoking, stress

23

Disturbance in regulation of Disturbance in regulation of
testicular function

Genetic level
 Hypothalamic level
 Pituitary level
 Target tissue level Target tissue lev

24

describe illness in which seprm production is compromised

androgen insensitivity syndrome, Hyperprolactinaemia, kallman syndrome, kinefelter syndrome xxy