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Flashcards in Hypothalamus and pitutitary Deck (23)
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1

List six hormones produced by the anterior pituitary

ACTH, FSH+LH,TSH,Prolactin, GH, msh

2

Where is CrH produced, what is it chemical nature and function

hypothalamus Corticotropin releasing hormone
(CRH)
41 amino acids

3

Where is GnRH porduced and what is it chemical sturcture

hypothalamus Gonadotropin releasing hormone
(GnRH)
10 amino acids

4

where is dopamine released and it's function

at hypothalamus function Prolactin inhibitor

5

what hormone acts as a prolactin releasing horomone and where is it synthesized

TRH hypothalamus

6

what hormones from hypothalamus control growth hormone relase

GHRH activates and stomatostatin which inhibits release

7

where is TRH made and what is it's chemical makeup

produced in hypothalamus hypothalamus
Thyrotropin releasing hormone
(TRH)
3 amino acids

8

prolactin chemical structure

Chemical structure
198 amino acids

9

prolactin actions on the body

In pregnancy promotes additional breast development
Post-partum stimulates milk production

10

what hormones come from posterior pituitary

oxytocin and adh

11

How do oxytocin and prolactin interact for breastfeeding

prolactin milk production and oxytocin is milk ejection

12

what does Hyperprolactinaemia cause

galactorrhoea
milk secretion from breast
gynaecomastia
excess breast growth in males
infertility
males and females

13

how do you treat hyperprolactinaemia

Treatment D2 agonists
cabergoline
bromocriptine

14

How does hyperprolactinaemia cause infertility

causes milk production
in lactating mother and supresses
menstrual cycle

15

what is Growth hormone
Chemical structure

191 amino acids, species specific

16

What are does growth hormone do and act on specifically

Growth of long bones until fusion of epiphyses
Increase in size of viscera
Anti-insulin effects
Metabolic effects related to growth
anabolic for protein
catabolic for fats and carbohydrates

17

What physiological factors cause GH secretion

Physiological
episodic
exercise
stress
physical
psychological
sleep
postprandial glucose decline

18

what are the pharmacological factors causing GH secretion

Pharmacological
drug-induced hypoglycaemia
amino acid infusions
small peptide hormones
monoaminergic stimuli

19

What are the clinical conditions associated with hyper secretion of growth hormone

Hypersecretion
gigantism before fusion of epiphyses
acromegaly after fusion of epiphyses

20

What are the clinical conditions associated with hypo secretion of growth hormone

Hyposecretion
Short stature before fusion of
epiphyses
Adult growth hormone deficiency after
fusion of epiphyses

21

Treatments for acromegaly

Trans-sphenoidal surgery
Bromocriptine/carbegoline D2 agonists
octreotride long acting somatostatin
lanreotide analogues
SSTR2 agonists
pasireotide
SSTR5 agonist

22

How do you treat small stature

Treat with recombinant hGH (somatropin) or
recombinant hIGF-1 (mecasermin)

23

What is the precursor molecule for posterior pituitary hormones

Synthesised with neurophysin as precursor in cell
bodies in supraoptic nucleus (SON)