Cook: Drugs are bad, m'kay.... Flashcards Preview

Reproductive > Cook: Drugs are bad, m'kay.... > Flashcards

Flashcards in Cook: Drugs are bad, m'kay.... Deck (89)
Loading flashcards...
1

oxytocin

Uses: induction of labor, contractions after C-section or during uterine surgery, control postpartum hemorrhage, abortion

2

prostaglandins

use: onset of labor

3

dinoprostone

PGE2
use: induce labor

4

misoprostol

PGE1
use: induce labor

5

carboprost tromethamine

15-methyl-PGF2
use: induce labor

6

tocolytics

Use: delay premature parturition to slow delivery long enough for therapeutic measures including glucocorticoid therapy to increase pulmonary surfactant
CI: intra-amniotic infection, fetal demise, severe fetal growth restriction, pre-eclampsia

7

magnesium sulfate

tocolytic
MOA: decrease Ca availability
oral (laxative), parenteral
Tx: anticonvulsant (depress CNS, block peripheral NM transmission), hypomagnesemia, preeclampsia, eclampsia
also neuroprotective to fetus
excretion: renal: Mg reabsorbed
CI: myasthenia gravis, caution in renal insufficiency
AE: flushing, blurry vision/ headache, nausea, hypotension,, lethargy, pulmonary edema
toxicity: loss of pateller reflexes, decreased urine output, respiratory depression

8

indomethacin

tocolytic
MOA: COX inhibitor
AE: GI, platelet dysfunction
fetus: premature closure of ductus arteriosus, oligohydramnios

9

caster oil

herbal
tocolytic (Cook)
induce labor (article)

10

blue cohosh

herbal
tocolytic (Cook)
induce labor (article)

11

black cohosh

herbal
tocolytic (Cook)
induce labor (article)

12

oil of evening primrose

herbal
tocolytic (Cook)
induce labor (article)

13

gonadotropins

Use: female infertility in anovulatory women or women with hypogonadism, in vitro fertilization; male infertility reserved for time fertility is desired
Risk: multiple pregnancy (preferred in men due to this)
PULSATILE

14

pregnancy diagnostic kit

Ab to B subunit of CG
qualitative CG detection in urine

15

How can you determine the exact time of ovulation?

measure urinary LH: ovulation occurs 36 hours after onset of LH surge

16

menotropin

IM: FSH and LH
SC: rFSH

17

chorinoic gonadotropin

IM
CG: binds LH receptor

18

estrogen MOA

nuclear receptor: receptor/ligand complexes bind DNA near HRE (hormone response element)
native: rapidly degrades so can't use

19

ethinyl estradiol

synthetic estrogen
decreased hepatic metabolism
use: combination pill

20

SERM (selective estrogen receptor modulator)

estrogen activity is tissue selective
activity: bone, brain, liver
no activity or antagonistic: breast, endometrium
Tx: breast CA

21

tamoxifen

SERM

22

raloxifene

SERM

23

combination pill (contraception)

estrogen: ethanol estradiol or mestranol
progestin: norethindrone, norgestrel, or levonorgestrel
MOA: prevents LH and FSH release by feedback inhibition
CI: thromboembolic disease, cerebral vascular disease, MI, CAD, congenital hyperlipidemia, breast CA, endometrial CA
off label use: polycystic ovary syndrome

24

mini-pill (contraception)

progestin only
blocks ovulation in ONLY 60-80% of cycles, impair sperm transport by thickening cervical mucus, decreases motility of ovules in oviduct, alters endometrium to impair implantation
slightly HIGHER failure rate than combination pill
for: breastfeeding women, over 35 yrs and smoke

25

postcoital contraception

morning after pill: two doses levonorgestrel separated by 12 hours
first does within 72 hours
most effective emergency contraception

26

contragestation

antiprogestin

27

mifepristone- RU48

antiprogestin: block progesterone binding to receptor
use: termination of pregnancy within 49 days

28

clomiphene

anti-estrogen: pure antagonist
act on ER in hypothalamus to block feedback inhibition of natural estrogens and stimulate GnRH which stimulates LH/FSH leading to ovulation
use: ovulation induction

29

fulvestrant

anti-estrogen: pure antagonist
act on ER in hypothalamus to block feedback inhibition of natural estrogens and stimulate GnRH which stimulates LH/FSH leading to ovulation
use: ovulation induction

30

mestranol

synthetic estrogen
decreased hepatic metabolism
use: combination pill