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Flashcards in Path Pics Deck (162)
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1

normal placenta

first trimester chorionic villi: central stroma surrounded by two layers of epithelium

double arrow (outer layer): syncytiotrophoblasts

single arrow (inner layer): cytotrophoblasts

2

normal placenta

third trimester chorionic villi: stroma with dense network of dilated capillaries surrounded by markedly thinned out syncytiotrophoblast and cytotrophoblast

3

Listeria: non-pasteurized milk, cheese

NECROTIZING INTERVILLOSITIS

4

chorioamnionitis: maternal inflammatory response

5

Umbilical Cord

INFECTION

top: phlebitis, arteritis in umbilical arteries and veins

middle: necrotizing funisitis due to long standing infection (right)

bottom: peripheral funitis (inflammation at periphery of umbilical cord) with CANDIDA 

6

chronic villitis with CMV (OWL EYE nuclear inclusion)

7

left: Bone Marrow

right: placenta

Parvovirus B19: ERYTHEMA INFECTIOSUM (SLAP CHEEK)

left: viral inclusions in early erythroid precursors

right: erythroblasts in the lumen of capillary vessels of placental villi show eosinophilic nuclear inclusions

8

Fetal Membranes

Neg. iron stain

MECONIUM in amnionic cavity

9

choroinic villi of plactenta

left: first trimester

right: 3rd trimester (increased vascularity)

cells: outer: syncytiotrophoblasts; inner: cytotrophoblasts

10

ectopic pregnancy in uterine tube

11

placenta accreta

placental villi interdigitate directly with the uterine myometrium, without an intervening decidual plate

12

abruptio placenta

BLOOD

13

Amnion Nodosum

gross: multiple yellow tan superficial amniotic lesions, usually near insertion of umbilical cord

micro: nodules of eosinophilic fibrous material with entrapped squamous cells

14

Potters sequence

cranial anomalies, clubbed feet, pulmonary hypoplasia

due to oligohydramnios

15

Preeclampsia

top: small placenta due to preeclampsia

bottom: placenta with pale infarct (more than 1/3 to 1/2 becomes infarcted: blood supply to infant can become compromised and cause fetal demise)

can also find hematomas

16

placenta

Preeclampsia

villous ischemia: increased syncytial knots (purple nubbins on villi)

17

maternal vessels in decidua

Preeclampsia

fibrinoid necrosis 

18

Complete hydatidiform mole

 villous enlargement, edema, and circumferential trophoblast proliferation

19

ultrasound

Complete hydatidiform mole

SNOWSTORM 

20

Partial hydatidiform mole

villi: some normal, others swollen, avascular and grape-like

minimal trophoblastic proliferation

21

Complete hydatifiform mole

grape-like

22

Partial hydatidiform mole

23

Choriocarcinoma

NO villi

mitoses

cytotrophoblasts, syncytiotrophoblasts

24

Choriocarcinoma

proliferating syncytiotrophoblasts, cytotrophoblasts

NO villi

mitoses

25

Necrotizing enterocolites (NEC)

A: entire small bowel is distended with perilously thin wall (impending perforation)

B: congested ileum: hemorrhagic infarction and transmural necrosis

arrows: submucosal gas bubbles (pneumatosis intestinalis)

26

right: Hyaline membrane disease (eosinophilic thick hyaline, atelectasis of alveoli)

left: normal fetal lung

27

hydrops fetalis

fluid accumulation: particularly prominent in soft tissue of neck (CYSTIC HYGROMA: classic in 45X)

28

Fibrocystic changes

(yellow is fat)

29

Fibrocystic change

Pos. if stain for myoepithelial 

30

Fibrocystic change: non-proliferative

APOCRINE METAPLASIA