CORTEXT week 2

Question 1

What is an arthropathy?

Answer 1

Disease of a joint

Question 2

What is arthritis?

Answer 2

Inflammation of a joint

Question 3

What is arthralgia?

Answer 3

Pain in a joint

Question 4

What are the 2 main categories of arthritis?

Answer 4

Non-inflammatory

Inflammatory

Question 5

What are the 2 categories of inflammatory arthritis?

Answer 5

Seropositive arthritis

Seronegative inflammatory arthropathy

Question 6

What are some seropositive arthritis?

Answer 6

Rheumatoid arthritis
Lupus
Scleroderma
Vasculitis
Sjogren's

Question 7

Whats are some seronegative inflammatory arthropathies?

Answer 7

Ankylosing spondylitis
Psoriatic arthritis
Reactive arthritis
IBD arthritis

Question 8

What is a seropositive condition?

Answer 8

Presence of auto-antibodies in serum

Question 9

What is anti-CCP antibody associated with?

Answer 9

Rheumatoid arthritis

Question 10

What is ANA associated with?

Answer 10

SLE
Sjogren's
Sclerosis
MCTD
Autoimmune liver disease

Question 11

What is Anti-dsDNA associated with?

Answer 11

SLE

Question 12

What is anti SM associated with?

Answer 12

SLE

Question 13

What is anti-Ro associated with?

Answer 13

SLE

Sjogrens

Question 14

What is anti-la associated with?

Answer 14

Sjogrens

Question 15

What is anti-centromere associated with?

Answer 15

Systemic sclerosis (limited)

Question 16

What is anti-scl-70 associated with?

Answer 16

Systemic sclerosis (diffuse)

Question 17

What is anti-RNP associated with?

Answer 17

SLE

Mixed connective tissue disease

Question 18

What is anti-jo-1 associated with?

Answer 18

Myositis

Question 19

What is Anti-cardiolipin antibody and lupus anti-coagulant associated with?

Answer 19

Anti-phospholipid syndrome

Question 20

What is ANCA associated with?

Answer 20

Small vessel vasculitis

Question 21

What is the most common form of arthritis?

Answer 21

Osteoarthritis

Question 22

What are some causes of secondary Osteoarthritis?

Answer 22

Congenital dislocation of the hip
Perthes
SUFE
Previous intra‐articular fracture
Extra‐articular fracture with malunion
Osteochondral / hyaline cartilage injury
Crystal arthropathy
Inflammatory arthritis (can give rise to mixed pattern arthritis)
Meniscal tears
Genu Varum or Valgum

Question 23

What is seen on OA x-ray?

Answer 23

Loss of joint space
Osteophytes
Sclerosis
Subchondral cysts

Question 24

What are the four groups of inflammatory arthropathies?

Answer 24

Seropositive
Seronegative
Infectious
Crystal deposition disorders

Question 25

What is the main treatment for inflammatory arthopathies?

Answer 25

``` Analgesia Anti-inflammatory -Steroids and NSAIDs Steroid injections DMARDs ```

Question 26

What are the symptoms of inflammatory arthritis?

Answer 26

``` Joint pain with associated swelling Morning stiffness Improvement in symptoms with exercise Synovitis on examination Raised inflammatory markers (CRP and plasma viscosity) Extra-articular symptoms ```

Question 27

What is the most prevelant seropositive inflammatory arthropathy?

Answer 27

Rheumatoid arthritis

Question 28

Where does RA affect?

Answer 28

Small joints of hands and feet | Knees shoulders and elbows can be affected

Question 29

Which gender gets RA more?

Answer 29

Women