Corticosteroids Flashcards
1
Q
name five corticosteroids
A
beclametasone budesonide prednisolone hydrocortisone dexamethasone
2
Q
what do they target?
A
cytosolic glucocorticoid receptor
3
Q
agonist/antagonist?
A
agonist
4
Q
how do they work ?
A
alters DNA expression
inhibits T-cell activation
prevents inflammation via inhibiting phospholipase A2, COX-2, cytokine an IgE formation
Inhibits IL2 so T cell activation - ^^ lipocortin
5
Q
what are they used for?
A
1st line asthma prophylaxis inflammation hypocortisolism (replacement )
6
Q
adverse effects?
A
oropharyngeal candidiasis growth retardation adrenal suppression hypertension bruising moonface and buffalo hump
