K+ sparing (aldosterone independant )

Question 1

name a K+ sparking aldosterone independent diuretic

Answer 1

amiloride

Question 2

what do they target?

Answer 2

epithelial sodium channel (EnaC) in DCT

Question 3

agonist/antagonist?

Answer 3

inhibitor

Question 4

what do they do?

Answer 4

reduce movement of Na across apical membrane

reduce Na reabsorption
reduce K secretion

Question 5

what are they used for?

Answer 5

aldosteronism liver ascites

resistant hypertension

Question 6

adverse effects?

Answer 6

oto and nephrotoxicity
hypotension
decrease Na
increase K

Question 7

prescribing advice ?

Answer 7

NOT with 
ACE-I
ARBs
B-Blockers 
NSAIDs