K+ sparing (aldosterone dependant ) Flashcards
1
Q
name a K+ sparing aldosterone dependant diuretic
A
Spironolactone
2
Q
what does it target?
A
intracellular aldosterone mineralcorticosteroid receptor in DCT
3
Q
agonist/antagonist ?
A
antagonist
4
Q
what do they do ?
A
prevent action of aldosterone
reduce fluid retention
reduce vasoconstriction
5
Q
what are they used for?
A
aldosteronism liver ascites
resistant hypertension
6
Q
adverse effects?
A
oto and nephrotoxicity hypotension decrease Na increase K Sexual dysfunction
7
Q
Prescribing advice
A
NOT with ACE-I ARBs B-Blockers NSAIDs
