covid

Question 1

What is zoonotic transfer

Answer 1

animlas to species

Question 2

• Why were SARS and MERS able to be controlled, even when they when they had extremely high mortality rates? (What makes their pattern of infection different the Covid-19)

Question 3

• How does the exterior of the virus compare to the bacteriophage virus that Hershey and Chase used?

Question 4

• The Spike Protein:
  Why might the high rate of mutations on the outer surface of the spike protein help the virus evade the host’s immune system?

Answer 4

its like a snare protein. the spikes help it spill its guts into the hosts

Question 5

The ACE2 protein is the “receptor” for the virus on our cells. What other type of protein is necessary, however, for infection?
How does the Virus particle infect our cells?
What normal cellular process does this seem most similar to?

Answer 5

TMRPSS2- a membrane protease

Question 6

What is meant by a Positive Strand RNA genome?
What does that mean upon infection?
How is that different than a HIV or other retrovirus genome?

Answer 6

templates for both translation and replication leading to interactions between host translation and RNA replication

Question 7

What is CRISPR DNA and how does a bacterium use it?

Answer 7

hort palindromes of DNA that are repeated, but seperated by spacer DNA. Spacer DNA is a record of Phages infections to it

Question 8

• If there are at least 93 CAS (Crispr Associated Proteins), what is so special about CAS9?

Answer 8

Programale nuclease that can cut DNA at any sequence

Question 9

• If there are at least 93 CAS (Crispr Associated Proteins), what is so special about CAS9?

Answer 9

Programale nuclease that can cut DNA at any sequence

Question 10

• Upon infection in a bacterium, how does it use the CRISPR DNA to fight off an infection?

Answer 10

• We define a gRNA. Which is a guide RNA that substitues crRNA with a custon RNA Cleave inactive overactive genes . gRNA will look for a complemenrty start to start cutting and create cleavage.

Question 11

What is the difference between CRISPR DNA and crRNA?

Answer 11

crRNA- RNA transcrip that came from DNA CRISPR
DNA sequence conist of one spacer and one palindrone.

Question 12

ORF

Answer 12

open reading fram, codes non structure proteins needed right away after infection