krebs Flashcards
What products remain at the end of glycolysis
Pyruvate oxidation
Does it involve a change in location for the metabolism intermediates, in this case the Pyruvate
since only Eukaryotes have mitochondria, does this mean that only eukaryotes have the Krebs cycle or an Electron Transport System
No, bacteria and archaea can still perform those functions. Mitochondria was once bacteria but evolved to specialize those functions. Bacteria and archea just dont specialize in those functions.
What type of enzyme brings Pyruvate into the Mitochondria? How does its mechanism lend credence to the idea that Mitochondria are derived from bacteria?
Pyruvate proton symporter- Proton pumps are pumping protons into the inner membrane space creating a gradient/ potential energy. Protons pumps are also seen in bacteria and lead to the idea of endosymbiosis.
he oxidation of Pyruvate to Acetyl Co-A involves what sequence of events
Step one: carboxyl group lost from Peru ate and relaxed CO2
Step two: NAD + gets reduced to NADH. Pyruvate gets oxidized.
Step three: CoA attaches to what is left of the pyruvate.
Where else in the actual Krebs cycle do we see that same sequence of events (may not include Coenzyme-A as a co-factor each time)?
In the citrate acid cycle- between intermediates, we will see CO2 leaving, NAD+ getting reduced to NADH, and a coenzyme joining into the cycle.
what is the main product(s) of the Krebs cycle?
Citrate?
2 molecules of CO2
3 molecules of NADH
1 molecule of FADH2
If the Cellular [ATP] is high, and the Krebs cycle slows down, which intermediate can exit the cycle (and the mitochondria) to inhibit Phosphofructokinase, thereby slowing down Glycolysis?
Citrate- Its the first product in the CAC. If there is lots of ATP, the intermediates can begin to slow down and citrate can leave the mitochondria (since its an ion) to inhibit Phosphofructokinase.
