Creutzfeldt-Jakob and Variant Creutzfeldt-Jakob Diseases

Question 1

CJD and vCJD belongs to a group of degenerative, infectious neurologic disorders called

Answer 1

Transmissible Spongiform Encephalopathies (TSTE)

Question 2

vCJD is the human variation of

Answer 2

Bovine Spongiform Encephalopathy (Mad Cow Disease)

Question 3

which cause TSE, are pathogens smaller than a virus that are resistant to standard methods of disinfection and sterilization.

Answer 3

Prions

Question 4

Although CJD and vCJD have distinct clinical features, one characteristic they share is

Answer 4

lack of CNS inflammation

Question 5

CJD that occurs spontaneously with no risk factors.

Answer 5

Sporadic Creutzfeldt-Jakob Disease

Question 6

This form is acquired by contaminated brain, tissue, or neurosurgical instruments and accounts for less than 1% of cases.

Answer 6

Acquired Creutzfeldt-Jakob Disease

Question 7

After clinical presentation, people with vCDJ survive an average of

Answer 7

14 months

Question 8

After clinical presentation, those with CJD survive for less than

Answer 8

1 year

Question 9

the only way to confirm diagnosis, is not recommended.

Answer 9

Brain Biopsy

Question 10

The three clinical diagnostic tests currently used in suspicious clinical presentations to support the diagnosis of CJD are

Answer 10

*immunologic assessment
*EEG
*MRI scanning

Question 11

Immunologic assessment of CSF detects a

Answer 11

Protein Kinase Inhibitor (14-3-3)

Question 12

The presence of this inhibitor indicates a neuronal cell death, which is not specific to CJD but does support the diagnosis.

Answer 12

Protein Kinase Inhibitor (14-3-3)