Crohn's Disease Flashcards
1
Q
Aetiology?
A
may be genetic susceptibilty- NOD2 gene association
2
Q
Pathology?
A
chronic transmural non-caseating granulomatous inflammation
3
Q
where does it affect?
A
anywhere in GIT but terminal ileum predominantly
4
Q
Characteristic presenting symtpoms?
A
- weight loss
- abdominal pain
- diarrhoea
- nausea/ vomiting
- fever & lethargy
5
Q
pathophysiological changes?
A
Cobblestone mucosa
Rosethorn ulcers
Obstruction, stricture
Hyperplasia of mesenteric lymph nodes
Narrowing of lumen
Skip lesions
6
Q
sign?
A
oral apthous ulcers
7
Q
extraintestinal signs?
A
- clubbing
- erythema nodosum
8
Q
systemic signs?
A
- fever
- tachycardia
9
Q
Investigations?
A
- Bloods - ESR, CRP, FBC
- Stool- MC&S, CDiff toxin, foecal calprotectin
- Imaging
- AxR
- CT/MRI
- barium X-Ray
- ileocolonoscopy + biopsy (or endoscopy if gastro-duodenal disease)
10
Q
what would the blood test findings be?
A
CRP, ESR and WCC raised
11
Q
Pharmacological management?
A
Pharmacological:
first presentation–> Prednisolone
second inflammatory exacerbation –> ADD Azathioprine
12
Q
When is surgery done in Crohn’s?
A
only if medical management fails
