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Biochem block 3 > CT 2 > Flashcards

CT 2 Flashcards

(111 cards)

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1
Q

❂ Laminins

A

(basal laminae) (GP)

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2
Q

fibronectin

A

widely distributed GP

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3
Q

Collagens

A

most widely distributed protein in the body(GP)

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4
Q

Tf Glycoproteins have covalently-bound carbohydrate.

A

t Glycoproteins have covalently-bound carbohydrate.

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5
Q

the hydroxyl group ( -OH ) of serine or threonine • the hydroxyl group ( -OH ) of hydroxylysine

A

called “O-linked” in GP

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6
Q

(only in collagens)

A

hydroxylysine in GP

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7
Q

the amide group [-NH2] of asparagine -

A

called “N-linked”.

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8
Q

tf sugar residue Render glycoproteins more hydrophilic

A

t

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9
Q

sugar residues stabilize against —– and ——- binding to some components

A

Sugar stabilize against hydrolysis and modulate binding to some components

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10
Q

Linker Proteins

A

Fibronectins

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11
Q

Interlink collagens, proteoglycans with cell surface receptors

A

Fibronectins

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12
Q

Fibronectin

A

Enable cells to interact with the extracellular matrix

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13
Q

Adhesion ❂ Differentiation

A

Fibronectin purpose

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14
Q

Fibronectin purpose

A

Embryonic cell migration

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15
Q

Fibronectin Determine —-, ——- organization

A

Determine cell shape, cytoskeletal organization

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16
Q

Wound healing

A

Fibronectin

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17
Q

cancer cells lose the ability to synthesize ———

A

cancer cells lose the ability to synthesize fibronectin

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18
Q

In OC, fibronectin regulates

A

Dental mesenchyme differentiating into odontoblasts

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19
Q

Carbohydrate accounts for —– of the weight of fibronectin

A

5%

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20
Q

2 peptides connected in V like shape

A

Fibronectin

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21
Q

fibronectin —> 2 x 250 kDa chains linked by disulfide bond near the C-terminus.

A

2 x —– kDa chains linked by disulfide bond near the — -terminus.

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22
Q

Fibronectin

A

specialized domains for binding cell surface receptors and the extracellular matrix

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23
Q

links the outer components of the cell to the cell itself.

A

Fibronectin

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24
Q

RGD or RGDS

A

cell surface receptor-binding domain

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25
disulfide bonds connect fibronectin at
C terminal
26
on the fibronectin structure which binding domain is most near N terminal
Heparin and Fibrin binding domain
27
binding domain next to cell surface receptor bidning domain and near N terminal
fibrin binding domain
28
fibrin heparin binding domain
most near c terminal of fibronectin (N to C)
29
cell surface receptor binding domain
contains RGD or RGDS
30
Laminin
linker proteins
31
Enable epithelial cells to interact with the extracellular matrix
Laminin
32
Laminin
high affinity for Type IV collagen
33
diff ,adhesion
Laminin
34
Embryonic nerve axonal outgrowth Nerve regeneration after injury
laminin
35
Laminin in OC
contributing to terminal differentiation of ameloblasts and in enamel matrix formation.
36
may also contribute to the growth of ameloblastomas
Laminin
37
Expression of α2 and β2 of laminin
in fetal oral squamous epithelium
38
α2 and β2 of laminin
Re-expression of these in adult oral squamous cell carcinomas
39
low Carbohydrate(13%)
Laminin
40
Laminin
Specialized domains bind cell surface receptors and the extracellular matrix i.e. links outer components of the cell to the cell surface.
41
disulfide-linked heterotrimer
Laminin
42
α, β and γ chains
Laminin
43
cruciform shape
Laminin
44
Laminin molecules ------associate to form ------.
Laminin molecules self-associate to form aggregates.
45
For laminin
Nomenclature indicates chain composition
46
Laminin network formation involve
Ca
47
type 4 collagen and perlecan (extracelllar molecules)
bind laminin
48
integrin
bind laminin and fibronectin binding site for the linker proteins
49
transmembrane proteins and GP
integrin
50
The cytoplasmic side of integrins binds to ----- components. The extracellular domain of integrins binds to ----- and -----
The cytoplasmic side of integrins binds to cytoskeletal components. ❂ The extracellular domain of integrins binds to fibronectins and laminins
51
binds ECM and transmembrane proteins
fibronectins and laminins
52
linker protein-mediated “communication”.
fibronectins and laminins
53
alpha beta subunit
integrin
54
tf Cells can have 1 integrin receptors that link the cell to only one component of the extracellular matrix.
Cells can have multiple integrin receptors that link the cell to more than one component of the extracellular matrix.
55
The ------/----- sequence on the linker proteins binds specifically to the integrin receptors.
RGD/RGDS sequence on the linker proteins
56
Activation of integrins can lead to their --- and ------ of focal adhesions
Activation of integrins can lead to their clustering and formation of focal adhesions
57
C terminus of alpha and beta subunits of integrin
located in cytoplams
58
alpha subunit split into 2 segments
and linked together by disulfide linkage
59
disulfide rich repeats exist in
beta subunit of integrin
60
integrin binds to actin on
cytoskeleton side
61
out to in signal of integrin
ligand binds from ECM
62
Out to in signal in integrin
cell polarity surviva; proliferation cytoskeletal structure gene expression
63
Talin
involved in in to out signaling with integrin
64
cell migration cell adhesion ECM assembly
In to Out signaling with integrin
65
regulation of the extracellular binding activity of a cell's integrins from within.
66
collagen
GP
67
Chemotaxis
Collagen
68
(major stress-bearing component
Colagen
69
Collagens form ----- fibers with high ---- strength; hold cells together in discrete units.
Collagens form insoluble fibers with high tensile strength; hold cells together in discrete units.
70
By weight, ---- of the protein in vertebrates is collagen
By weight, 1/4 of the protein in vertebrates is collagen
71
cornea cartiledge
high percent collagen by weight 64 50
72
highest percent collagen by weight
skin 74
73
liver lung
small percent colagen by wieght 4 and 10
74
cOrtical Bone aOrta
23% 10-24% % collagen by wieght
75
after fibroblast make polypeptide system
OH and glycosylation occurs(collagen)
76
Secretion of procolllagen is followed by
hydrolysis of peptide bond to form tropocollagen
77
self assembly of tropocolagen to form
collagen fibers
78
crosslink in colagen fiber leads to
mature collagen fiber
79
tf collagen fber is made in between procolagen and tropocollagen
F after tropocollagen
80
tf collagenis product of few genes and few types
F over 40 genes 28 types
81
types 2 and 3 collagen
homotrimers
82
collagen 1,4,5
heterotrimers
83
polppetide in collegen
alpha
84
placenta skin
type 5 collagen
85
basment membrane
type 4 collagen
86
cartildge IVD
collagen 2
87
skin tendon
type 1 collagen
88
bone dentin
type 1 collagen
89
BV uterus reticular fibers
type 3 collagen
90
triple helical rod
collagen
91
Remarkably strong Forms an insoluble fiber with high tensile strength
collagen
92
collagen
3000 Å long and 15 Å diameter
93
1/3 of the amino acids in collagen
Glycine
94
Proline 4-Hydroxyproline (Hyp) 3-Hydroxyproline (Hyp)
collagen
95
5-Hydroxylysine
collagen
96
tf collgen has Charged (---) amino acids
F Charged (positive) amino acids
97
highest component in collagen and elastin
Gly
98
5 hydroxylysine
not present in elastin present in collagn
99
desmosine and isodesmosine not in
collagen
100
collagen primary structure
glu X Y
101
X
Proline
102
Y
hydroxyproline
103
polar basic AA
also in collagen
104
X
proline
105
tf 3 hydroxylysine is in collagen
F 5 hydroxylysine
106
Y
hydroxyproline
107
108
secondary structure of collagen
tropocollagen with left handed helical structure
109
type 2 trans helix
2nd and tert structure of Collagen
110
quat structure
type 2 transhelix twist around each other to form right handed helix(superhelix)
111
triple helix of tropocollagen
has glycine in the middle

Biochem block 3 (12 decks)

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