CT 4 Flashcards
(49 cards)
Procollagen molecules are packaged and secreted by passing through the —
Procollagen molecules are packaged and secreted by passing through the Golgi.
Procollagen peptidases cleave the N- and C- terminal of
collagens (Types, I, II, III)
tropocollagen
cleaved product after procollagen
topocollagen
entire (Gly-X-Y]n region and telopeptides
deficiency in procollagen peptidases
Ehlers-Danlos Syndrome Type VII
Hyperextensible skin that bruises easily
Ehlers-Danlos Syndrome Type VII
Ehlers-Danlos Syndrome Type VII
Dislocation of major joints
1/4 stagger for fibril formation with 400 Å gaps between head and tail
tropocollagen
the site of cross-link formation i.e. where insolubilization takes place • nucleation site for calcium deposition in bone
Gaps of fibrils
The structure repeats every — rows.
5
Once the molecules are aligned, they are strengthened by —— cross-linking.
Once the molecules are aligned, they are strengthened by covalent cross-linking.
step 1 ;lysyl oxidases
Oxidation of lysyl (and hydroxylysyl) residues
step 2; Spontaneous condensations
of products of lysyl oxidase reactions form covalent bonds
from step 2; formation of these —– bonds between amino acids located on ——- tropocollagen molecules forms a strong fiber.
formation of these covalent bonds between amino acids located on adjacent tropocollagen molecules forms a strong fiber.
amino termini of lysyl residues are converted to ——-
amino termini of lysyl residues are converted to aldehydes.
need O2 and Cu
lysyl oxidase
aldol cross link
spontaneuous(alfter adehydes are made)
lysinornorluecine crosslink from
aldehyde and NH3+
lysyl oxidase crosslink
are spontaneous
lysyl amino oxidase
can yield one or two aldehydes
2 aldehydes goes thru aldol condensation
to make aldol
link between one aldehyde and Amino group is
lysinonurleucine
(cross link in collagen or elastin)
❂ Hydroxypyridinium
cross-linking of two hydroxylysyl residues and a lysyl residue
Hydroxypyridinium
in collagen
