signal transduction 5

Question 1

form FA

glycogen

pyruvate

Answer 1

Glucose infiltration throught the cell

Question 2

Glucose comes through the cell

Answer 2

through transporter Glut 4

Question 3

TF insulin on insulin receptor will trigger Glucoses to travel through Glucose transporter 4

Answer 3

T

Question 4

cysteine

Answer 4

on 2 alpha subunits of insulin receptor on ext

Question 5

constituitive tetramer

Answer 5

insulin receptor(2 alpha and 2 beta subunits)

Question 6

tf the insulin receptor has disulfide bond between

the alpha subunits and between the beta subunits

Answer 6

F

alpha-alpha

alpha beta

Question 7

after insulin binds its receptor

Answer 7

conf change and autophos occurs of the receptor

Question 8

beta subunit of insulin receptor

Answer 8

tyrosine kinase domain

Question 9

tf PTB domain is attracted to act insulin receptor before SH2 of PI-3K

Answer 9

T

Question 10

Insulin receptor substrate

Answer 10

has pth and ph domains on it

Question 11

PI 3k has 2 SH groups on it that bind to

Answer 11

PH domain of Irs

Question 12

conf change on IRS

Answer 12

phos by RTK

PI3k ataching to it

Question 13

tf PIP3 is broken to PIP2

Answer 13

F PIP2 is converted to PIP2

by PI3k

Question 14

pdk1 and pkb

Answer 14

have ph domains and are attracted to PM after PIP3 is made

Question 15

Pdk1 conf change and act on membrane

Answer 15

triiggers Pkb

ito move to PM and to be act and phos

Question 16

Glut 4 pushed to membrane

Answer 16

allows glucose to come into membrane

Question 17

Reduced insulin sensitivity characterized by elevated insulin in blood

Answer 17

Diabetes type 2

Question 18

Mixed, mostly serous

Answer 18

submandibular

Question 19

parotid

Answer 19

serous

Question 20

Sublingual

Answer 20

Mixed, mostly mucous

Question 21

symp nerves

Answer 21

protein secretion

Question 22

NE(from symp nerves) binding to receptor

Answer 22

trigger Camp to secrete proteins

Question 23

PS nerves

Answer 23

water/ions secretion

Question 24

Ach bind to receptor trigger

Answer 24

Ca to be secreted

Question 25

tf Symp and PS nerves are antagonistic

Answer 25

F act togethr in acinar cells

Question 26

Muscarinic ach receptors(gpcr)

Answer 26

fluid secretion

Question 27

beta adrenergic (gpcr)

Answer 27

binds NE and part of prtoein secretion

Question 28

alpha subunit act phospholipase C

Answer 28

Fluid secretion

Question 29

GPCR

Answer 29

puts ATP on G proteins(alpa subunit)

Question 30

converts PIP2 to DAG and IP3

Answer 30

phospholipase C

Question 31

role of ip3 in the fluid secretion

Answer 31

bind ip3 receptors of ER and releases Ca

Question 32

Activation of ion pumps/channels Formation of osmotic gradient

Answer 32

Ca in fluid secretion model

Question 33

AC

Answer 33

involved in proteins secretion pathway to convert ATP to Camp and finally make pka

Question 34

Exocytosis of preformed protein-containing vesicles Synthesis/packaging of new vesicles

Answer 34

pka in protein secretion model

Question 35

Salivary gland dysfunction

Answer 35

Xerostomia