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Flashcards in CV function in pathology Deck (19):
1

What are the consequences of circulatory shock?

Syncope after severe shock and inadequate blood to brain

Even after compensatory mechanism arterial pressure can be low

2

What is MAP?

Mean arterial pressure= CO*TPR

3

What are the 3 primary disturbances of circulatory shock?

-Severely depressed Myocardial function
-Grossly inadequate filling due to low mean circulatory filling pressure
-Profound systemic vasodilation

4

what volume of loss is considered hypovolemic shock?

>20%

5

How do exotoxins create vasodilation?

Formation of nitric oxide synthase in endothelial cells

6

What is neurogenic shock?

Loss of vascular tone due to inhibition of normal tonic activity of sympathetic vasoconstrictor nerves
- Vasovagal syncope
-General anesthesia

7

What are the sx's of compensatory circulatory shock?

Pallor
Cold clammy skin
Rapid HR
Muscle weakness
Venous constriction

8

What about when your compensatory response is weak?

Dizziness
Confusion
LOC

9

What are some other responses to circulatory shock?

Rapid breathing to increase VR
- Renin release (TPR)
- ADH release (TPR)
- Epi release
- Increase glycogenlysis of liver (rises extracellular osmolarity)
- reduced capillary hydrostatics--> resorption

10

How do we compensate for CAD?

Local metabolic vasodilation to reduced arterial resistance of coronaries

11

What is the definition of systolic dysfunction?

EF

12

What are some systemic alterations of systolic dysfunction?

Reduced Ca sequestration
- low affinity of trop for Ca
- Altered substrate metabolism from fatty acid and glucose oxidation
- Impaired respiratory chain activity- impaired energy production

13

What is the bad cause of long term compensation

Fluid retention leads to chronically high EDV
- increased O2 demand
- increased wall tension

14

What does high venous pressure cause?

Transcapillary fluid leading to filtration, edema and congestion

15

What is pulomonary HTN?

>20mmHg

16

Systemic HTN?

>140/90

17

What is primary HTN?

Essential
- 90%
- Treat symptom not cause
- Unknown etiology

18

What does HTN do to urinary output?

Shifts renal function curve to the right
- more aterial pressure is needed to get normal urinary output

19

how do we treat essential HTN?

Diuretic
Restrict sald
Beta blocker
Ace inhibitor