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Flashcards in Extra micro Deck (26):
1

What are some virulence factors of strep viridans?

Alpha hemolytic
Bile resistant
Optochin resistant (can live close to the chin)
Gram +
Adheres to fibrin platelet aggregates
Forms dextrans

2

What are some virulence factors of staph epidermidis?

Gram +
Catalase +
Urase +
Coagulase -
Novobiocin sensitive
Normal flora that contaminates blood cultures
Infects prothetics by producing adherent biofilms

3

What is the most common bacteria causing intravascular catheter infections? Sx's?

S. Aureus due to biofilm production
chills, fevers, Tenderness, purulent discharge and swelling

4

What is the timeline for infectious agents for prothetics valve placement infections?

Up to 1 year= Staph epidermidis 50% ad 20% staph Aureus
After 1 year= Strep Virdans

5

What about the timeline for pacemaker and defibrillator infectious agents? Sx's?

Up to 2 weeks= S Aureus
2weeks to 1 year= S Epidermidis
after 1 year= Strep Viridans

Fevers chills bacteremia as well as swelling, erythema and pain at implant site

6

If you have endocarditis sx's but negative cultures what is the most likely cause?

Coxiella burnetii
HACEK
Bartonella spp

7

What is significant about Coxiella burnetii on hx?

If you have parrots as pets
+ IgG Ab and on cultures

8

What are the virulence factors of HACEK organisms?

Must use blood argar
Fastidious gram - bacteria
Normal human biome-- around mouth

9

What criteria of Jones needs to be met for Dx? What does it dx/

Rheumatic Fever

1. 2 major and strep A infection evidence

2. 1 major and 2 minor and strep A infection evidence

10

What are the major Jones criteria?

J- Joints--> migrating polyarthrits
O- Heart problems (panscarditis)
N- Nodules Subcue
E- Erythema Marginatum
S- Sydenham's Chorea

11

What are the minor Jones criteria?

-Fever
-Arthralgia
-Increase CRP and ESR
-Prolong PR interval
-Previous rheumatic HD or rheumatic Fever

12

What is needed for evidence of prior Strep A infection?

Elevated ASO
Anti-DNase B titers

13

What is ASO?

Anti-streptolysin O
- Oxygen labile streptococcal hemolytic exotoxin

14

What are Janeway lesions and their cause?

Arterial emboli
- NON-tender hemorrhagic lesions on palms and soles
- Bacteria found in lesion

15

What are the immunologic phenomena that meet Dukes criteria?

Rheumatoid factor
Roth's spots
Osler's nodes

Type III hypersensitivity

16

What are Osler's nodes?

red purple slightly raised lumps on the pads of fingers and toes

17

What are some virulence factors of strep viridans?

-Dextran production/Glycocalyx formation
- surface adhesion proteins (FimA, GspB)

18

What are some virulence factors of Strep pneumonia?

capsules

19

What are some virulence factors of strep pyogenes?

Capsule
M protein

20

What are some virulence factors of neisseria meningitidis?

Capsule

21

What are some virulence factors of Enterococcus species?

Biofilm formation

22

What are some virulence factors of Staph Aureus?

-Capsule
-Biofilm formation
-Elastin, Collagen, Fibronetin (FnbpA) binding proteins
-Coagulase
- Leukocidin

23

What are some virulence factors of staph epidermidis?

-Sd repeat containing protein- G (SdrG)
-Biofilm formation (various proteins)

24

What are some virulence factors of Coxsackie A and B, Adenovirus?

Coxsackie-Adenovirus cellular receptor (CAR) binding proteins

25

What are some virulence factors of rickettsia rickettsia?

-OmpA and OmpB (attachment)
- Type 4 secretion system (T4SS) host cell entry

26

What do strep and staph use for attachment?

MSCRAMMs
- Microbial surface components recognizing adhesive matrix molecules