Cytokines Flashcards
1
Q
IL-1
A
Secreted by: Monocytes Macrophages PMNs Fibroblasts Epithelial Cells Endothelial Cells
Function:
- fever
- Th cell stimulation
- osteoclasts stimulation
2
Q
IL-2
A
Secreted by Th-1 cells
Stimulates other Th cells and Tc cells.
3
Q
IL-3
A
= Colony Stimulating Factor (CSF)
Produced by Th cells and NK cells
Stimulates hematopoietic stem cells
4
Q
IL-4
A
Produced by Th-2 cells
Stimulates B cells and IgE
5
Q
IL-5
A
Produced by Th-2 cells
Stimulates B cells, IgA and eosinophils
6
Q
IL-6
A
Produced by:
- monocytes
- macrophages
- fibroblasts
- Th cells
Function:
- fever
- stimulation of B cells, Th cells, osteoclasts
7
Q
IL-8
A
Secreted by monocytes and macrophages
Function: chemotaxis of PMNs
8
Q
IL-10
A
Secreted by Th-2 cells
Inhibits Th-1 cells
9
Q
IL-12
A
Secreted by monocytes and macrophages
Stimulates Th-1 cells
10
Q
INF-y
A
Produced by Th-1 cells
Stimulates monocytes, macrophages, NK cells, PMNs
11
Q
TNF-a
TNF-B
A
Secreted by:
- monocytes (a)
- macrophages (a)
- T-cells (B)
Function:
- molecules adhesion
- stimulates Th cells and osteoclasts
- cachexia (wasting syndrome)
12
Q
TGF-B
A
Secreted by monocytes, macrophages, T-cells, B-cells.
Function:
- “anti-cytokine”
- inhibits T-cells, B-cells, PMNs, monocytes, macrophages, NK cells
- stimulates collagen formation and wound healing
