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Flashcards in Demenita Deck (5)
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1

Overall MOA of acetylcholinesterase inhibitors

decrease AChE levels, thus increasing ACh levels throughout hte body

2

tertiary/uncharged AChE inhibitors (5)
Do they cross BBB?

donepezil
galantamine
physostigmine
rivastigmine
tacrine

Yes, do cross BBB = toxic.

3

quaternary/charged AChE inhibitors (5)
Do they cross BBB?

ambenonium
echothiophanate
edrophonium
neostigmine
pyridostigmine

No, do not cross BBB = safer

4

Which AChE inhibitors are reversible?

the carbamic acid esters - noncovalent
ambenoium, neostigmine, physostigmine, pyridostigmine

5

Antidote for overexposure to organophosphate

pralidoxime and benzodiazepine - give pralidoxime BEFORE aging has occurred.