Flashcards in Recap Deck (44)
Person has generalized anxiety with an acute onset of recent attacks. What drugs do you give them for short and long term?
What if they have a hx of heroin and alcohol abuse? Downside to this drug?
Short term - benzo
Long term - SSRI
Addictive personality - give buspirone, but it takes 1-2 weeks for effects.
Do not give fluoxetine with what S-H?
Do not give fluoxetine (SSRI) with Ramelteon (melatonin S-H) bc of CYP inhibiton by fluoxetine
Treatment of EPS
trihexylphenydyl, benztropene, diphenhydramine
EPS worst with?
Haloperidol and all typical anti-psychotics
sedation, muscarinic, hypotension
typicals - chlorpromazine, fluphenazine, haloperidol
indications for what drug: tx resistant schizophrenia and suicide.
adverse effects of clozapine -
monitor thyroid function in pts taking
prolonged QT interval
ziprasidone (atypical antidepressant)
elevated PRL levels
risperidone and Haloperidol (and all typical antipsychotics)
Main (only-ish) side effect is seizures when administered at high doses treatment for anorexia and bulemia, as well as 1st line tx of depression with hypersomnia.
Buproprion (NDRI - anti depressant)
High potency v. low potency typical antidepressants
High potency (neuro EPS) - fluphenazine, haloperidol
Low potency (alpha, Histamine, anti-cholinergic) - chlorpromazine
suicide prevention (two drugs)
lithium (antipsychotic mood stabilizer) clozapine (atypical antidepressant)
sexual dysfunction in 1/2 of all patients on ___ class
What does not cause sexual dysfunction?
Low potency anti-depressants have these side effects (along with TCAs)
alpha (orthostatic hypot), Histamine, anti-cholinergic -const/dry mouth/dizzy
Highly sedating antidepressant
Drug that inhibits reuptake of monoamines (NE, dop, 5HT). Increases sympathetics. Coronary artery vasospasm (Myocardial ischemia).
Best treatment for alcohol withdrawal.
Diazepam (long acting bezo- best). BAD for liver.
Lorazepam, oxazepam (short acting benzo). BETTER for liver.
What drug in treatment of alcohol dependence decreases cravings?
Mu-opioid receptor antagonist
What drug in treatment of alcohol dependence does not decrease cravings, but causes aversion?
ALDEHYDE dehydrogenase inhibitor
MOA of acamprosate.
NMDA receptor antagonist and GABA agonist.
Non-benzo used to treat insomnia.
Zolpidem and zaleplon (fall asleep), eszopiclone (stay asleep)
Neuroleptic Malignant Syndrome (antipsychotic side effect)
Autonomics (hypertension, hyperthermia, tachycardia)
acute dystonia (mm contractions), akathisia (leg restlessness), dyskinesia, parkinson-like movements (tremor, rigidity, bradykinesia, masked facies)
EPS (typical > atypical side effect)
Involuntary movement after chronic use (lip smacking).
Muscle contractions in EPS
Leg restlessness in EPS