Dementia Symposium Flashcards Preview

Year 2 C&M Clinical Symposia > Dementia Symposium > Flashcards

Flashcards in Dementia Symposium Deck (41)
Loading flashcards...
31

What is the characteristic abnormality in MRI in patient with variant CJD?

Abnormality in the posterior thalamic region - called pulvinar sign which is highly sensitive and specific for vCJD

32

Corticobasal degeneration falls into which molecular genetic classfication?

Tauopathy

33

What is the main feature corticobasal degeneration on electron microscopy?

Phospho-tau filaments with the neurons (also cytoplasmic tangles, neuropil threads)

34

If a patient presents with fitting and ongoing confusion what is the most likely diagnosis?

Encephalitis

35

Encephalitis due to Voltage gated postassium channel Ab (VGKC Ab LE) is what kind of encephalitis?

Autoimmune encephalitis

36

What are the 4 common signs and symptoms of VGKC Ab LE)

1) Subacute memory loss
2) Psychiatric/behavioural disturbances
3) Seizures - usually partial
4) Hyponatraemia in common

37

What sign do 60% of people with VGKC Ab LE shown on MRI?

Medial temporal lobe high signal on MRI

38

Does VGKC Ab LE cause treatable or untreatable dementia?

Treatable dementia - type of autoimmune enecephalitis which can be treated with steroid treatment

39

What is the prognosis of VGKC Ab LE?

Thymoma/SCLC (Small cell lung cancer) may also be present but isnt commonly associated
If no tumour is present then the prognosis is very good with immuno modulation

40

What kind of conditions are neurologists mainly concerned with in regards to dementia?

Treatable conditions

41

Which specialty deals with dementias caused by untreatable conditions?

Psychiatry