Flashcards in Dementia Symposium Deck (41)
What is the characteristic abnormality in MRI in patient with variant CJD?
Abnormality in the posterior thalamic region - called pulvinar sign which is highly sensitive and specific for vCJD
Corticobasal degeneration falls into which molecular genetic classfication?
What is the main feature corticobasal degeneration on electron microscopy?
Phospho-tau filaments with the neurons (also cytoplasmic tangles, neuropil threads)
If a patient presents with fitting and ongoing confusion what is the most likely diagnosis?
Encephalitis due to Voltage gated postassium channel Ab (VGKC Ab LE) is what kind of encephalitis?
What are the 4 common signs and symptoms of VGKC Ab LE)
1) Subacute memory loss
2) Psychiatric/behavioural disturbances
3) Seizures - usually partial
4) Hyponatraemia in common
What sign do 60% of people with VGKC Ab LE shown on MRI?
Medial temporal lobe high signal on MRI
Does VGKC Ab LE cause treatable or untreatable dementia?
Treatable dementia - type of autoimmune enecephalitis which can be treated with steroid treatment
What is the prognosis of VGKC Ab LE?
Thymoma/SCLC (Small cell lung cancer) may also be present but isnt commonly associated
If no tumour is present then the prognosis is very good with immuno modulation
What kind of conditions are neurologists mainly concerned with in regards to dementia?