Flashcards in Dermatology Pharmacology and Prescribing Deck (26):
What is 'off labels' medicine?
Licensed medication that is being used for n unlicensed indication
What is a 'specials' medicine?
Long history of use, no strong evidence base nut clinically effective
What are some of the causes of prescribing errors?
Lack of knowledge
Mistake writing/generating prescription
No local or national guidelines
What is pharmacokinetics?
The effect of the body on the drug
What is pharmacodynamics?
The effect of the dug on the body
What must be considered with pharmacodynamics?
Age of patient
What are some influences in adherence to medication?
Not paying for their prescription
What are some factors associated with poor adherence?
Slower acting agents
Multiple applications per day
Lack of patient education
Cosmetic acceptability of treatment
What is a vehicle?
Pharmacologically inert, physically and chemically stable substance that carries the active drug
What are the factors that effect absorption?
Chemical properties of the drug
Thickness and hydration of stream corneum
What are the different types of vehicles?
What are some examples of drugs which are used topically?
What effect will anti inflammatory and immunosuppressive drugs have?
Inhibit vascular permeability
Suppress fibroblast, endothelial and leukocyte function
How much should a finger tip unit treat?
Area double the size of one hand
What are the side effects of topical steroids?
Acne/rosacea/ perioral dermatitis
What are retinoids?
Vitamin A analogues
What are the 4 common oral retinoids used in dermatology?
What are the contraindications of retinoids?
Teratogenic (cardiac and neural birth defects)
What are the side effects of retinoids?
Chelitis and xerosis
Increases transaminases, increases triglycerides
What are some examples of immunosuppressants used in dermatology?
What are the contraindications of immunosuppressants?
Risk of malignancy and serious infection
What are biologics?
Genetically engineered proteins derived from human genes
What biologics are licensed for psoriasis treatment?
What biologic is licensed for chronic spontaneous urticaria?
What are the contraindications of biologics?
Risk of infection (TB reactivation, avoid live vaccines)
Risk of malignancy
Risk of demyelination (TNF inhibitors)