Psoriasis Flashcards Preview

Dermatology > Psoriasis > Flashcards

Flashcards in Psoriasis Deck (24):
1

What is psoriasis?

Sharply demarcated erythematous plaque with micaceous scale
Chronic imune mediated disease

2

How can psoriasis develop?

Polygenic predisposition + environmental triggers

3

What genes predispose for psoriasis?

HLA-Cw6 9 (chromosome 6)

4

What are the environmental triggers of psoriasis?

Infection
Trauma
Drugs
Sunlight

5

What is the pathogenesis of psoriasis?

Keratinocytes become stressed
Activation of dermal dendritic cells (dDCs)
dDCs travel to lymph nodes and present antigen to naive T cells
Interleukins and TBF alpha amplify inflammatory cascade, stimulate keratinocyte proliferation
Angiogenesis
Cell cycle reduced from 28 to 3-5 days

6

What is found in the histology of psoriasis

Hyperkeratosis
Neutrophils in stratum corneum
dilated dermal capillaries
T cell infiltration
Acanthosis

7

What examination should be completed for psoriasis?

Skin (Erythroderma, pustules)
Nails (Onocholysis, pitting, oil spots)
Scalp

8

What is Koebner phenomenon?

Surgery scar line can erupt in patient weeks after procedure who has psoriasis

9

What is the appearance of chronic plaque psoriasis?

Symmetric
Extensor surfaces

10

What can trigger guttate psoriasis?

Viral or bacterial infections

11

Who is commonly affected by guttate psoriasis?

Children and adolescents

12

What areas of the body does palm-plantar psoriasis affect?

Palms and soles

13

What can palms-plantar psoriasis be associated with?

Smoking
Sterile inflammatory bone lesions

14

What is a consequence of scalp psoriasis?

Alopecia

15

What can trigger flexural/inverse psoriasis?

Localised dermatophyte, candidate or bacterial infection

16

What is the appearance of pustular psoriasis?

Sterile pustules, sometimes systemic symptoms

17

What can pustular psoriasis associated with?

Pregnancy
Rapid stop of steroids
Hypocalcaemia
Infection

18

What is erythrodermic psoriasis also known as?

Red man syndrome

19

What is the differential diagnosis of psoriasis?

Seborrhagic dermatitis
Lichen planus
Mycosis fungoides
Bowens disease
Secondary syphillis
Contact dermatitis

20

What is the treatment for psoriasis by GP?

Emollients
Soap substitutes
Vitamin D3 analogues
Coal tar creams
Topical steroid
Salicylic acid

21

What treatments for psoriasis are managed by dermatologists?

Crude coal tar
Dithranol
UVB phototherapy

22

What are the systemic treatments for psoriasis?

Retinoid (Acitretin)
Immunosuppression (ciclosporin, methotrexate)
Biologic therapies

23

What is the treatment for eyrthrodermic psoriasis?

Admission
Fluid balance
Bloods/ IV access
Thick greasy ointment emollients

24

What is used to monitor the progress of psoriasis?

Psoriasis Area Severity Index (PASI)
Dermatology Life Quality Index (DLQI)