Flashcards in Psoriasis Deck (24):
What is psoriasis?
Sharply demarcated erythematous plaque with micaceous scale
Chronic imune mediated disease
How can psoriasis develop?
Polygenic predisposition + environmental triggers
What genes predispose for psoriasis?
HLA-Cw6 9 (chromosome 6)
What are the environmental triggers of psoriasis?
What is the pathogenesis of psoriasis?
Keratinocytes become stressed
Activation of dermal dendritic cells (dDCs)
dDCs travel to lymph nodes and present antigen to naive T cells
Interleukins and TBF alpha amplify inflammatory cascade, stimulate keratinocyte proliferation
Cell cycle reduced from 28 to 3-5 days
What is found in the histology of psoriasis
Neutrophils in stratum corneum
dilated dermal capillaries
T cell infiltration
What examination should be completed for psoriasis?
Skin (Erythroderma, pustules)
Nails (Onocholysis, pitting, oil spots)
What is Koebner phenomenon?
Surgery scar line can erupt in patient weeks after procedure who has psoriasis
What is the appearance of chronic plaque psoriasis?
What can trigger guttate psoriasis?
Viral or bacterial infections
Who is commonly affected by guttate psoriasis?
Children and adolescents
What areas of the body does palm-plantar psoriasis affect?
Palms and soles
What can palms-plantar psoriasis be associated with?
Sterile inflammatory bone lesions
What is a consequence of scalp psoriasis?
What can trigger flexural/inverse psoriasis?
Localised dermatophyte, candidate or bacterial infection
What is the appearance of pustular psoriasis?
Sterile pustules, sometimes systemic symptoms
What can pustular psoriasis associated with?
Rapid stop of steroids
What is erythrodermic psoriasis also known as?
Red man syndrome
What is the differential diagnosis of psoriasis?
What is the treatment for psoriasis by GP?
Vitamin D3 analogues
Coal tar creams
What treatments for psoriasis are managed by dermatologists?
Crude coal tar
What are the systemic treatments for psoriasis?
Immunosuppression (ciclosporin, methotrexate)
What is the treatment for eyrthrodermic psoriasis?
Bloods/ IV access
Thick greasy ointment emollients