Skin Cancer Flashcards Preview

Dermatology > Skin Cancer > Flashcards

Flashcards in Skin Cancer Deck (23):
1

What are the risk factors for non melanoma skin cancer?

UV radiation
Photochemotherapy
Chemical carcinogens
X ray and thermal radiation
Human papilloma virus
Familial cancer syndromes
Immunosuppression

2

What is the clinical appearance of basal cell carcinoma?

Slow growing
Locally invasive
Telangiectasia
Central ulceration
Pearly rolled edge

3

What is the treatment for basal cell carcinoma?

Excision
Curettage
Mohs surgery
Vismodegib

4

What are the indications for vismodegib?

Locally advanced BCC not suitable for surgery or radiotherapy
Metastatic BCC

5

What are the side effects of vismodegib?

Hair loss
Weight loss
Altered taste
Muscle spasms
Nausea
Fatigue

6

What is the clinical appearance of squamous cell carcinoma?

Faster growing
Tender
Scaly/crusted
Fleshy growths
Can ulcerate

7

What is the treatment for squamous cell carcinoma?

Excision
Radiotherapy

8

What is the criteria for a high risk squamous cell carcinoma?

Immunosuppressed
Diameter >20mm
>4mm depth
Ear, nose, lip, eyelid
Perineural invasion
Poorly differentiated

9

What is the origin of a keratoacanthoma?

Hair follicle in sun damaged skin

10

What is the treatment for keratoacanthoma?

Excision

11

What are the risk factors for melanoma skin cancer?

UV radiation
Fair skin, red hair, blue eyes
Tendency to burn easily
Familial melanoma and melanoma susceptibility genes

12

What is the ABCDE rule?

Asymmetry
Border
Colour
Diameter
Evolution

13

What are the major features of melanoma skin cancer?

Change in size
Change in shape
Change in colour

14

What are the minor features of melanoma skin cancer?

Diameter more than 5mm
Inflammation
Oozing or bleeding
Mild itch or altered sensation

15

What are some types of melanoma skin cancer?

Superficial spreading malignant melanoma
Lentigo maligna melanoma
Nodular melanoma
Acral lentiginous melanoma
Ocular melanoma
Metastatic melanoma

16

What is the treatment for melanoma skin cancer?

Urgent wide margin surgical excision (Breslow thickness)
Sentinel lymph node biopsy
Chemotherapy/immunotherapy
Regular follow up
Primary and secondary prevention

17

What are the biologics used to treat metastatic melanoma?

Ipilimumab
Pembrolizumab
Vemurafenib

18

What cells are can be affected by cutaneous lymphoma?

Cutaneous T cell
Cutaneous B cell

19

What are the different stages of mycosis fungoides?

Patch
Plaque
Tumour
Metastatic

20

What is sezary syndrome also known as?

Red man syndrome

21

What is the treatment for cutaneous lymphoma?

Topical steroids
PUVA or UVB
Localised radiotherapy
Interferon
Bexarotene
Low dose methotrexate
Chemotherapy
Total skin electron beam therapy
Extracorporeal photophoresis
Bone marrow transplantation

22

What are the steps of extracorporeal photophoresis?

Patients blood drawn and leucocytes collected
WBC mixed with psoralen, makes T cells sensitive to UVA radiation
Exposed to UVA radiation, damges diseased cells
Treated cells re infused back to patient

23

What is the management for cutaneous metastases?

Treat underlying malignancy
Local excision
Localised radiotherapy
Symptomatic