Flashcards in Developmental Biology Deck (46):
Genetic female sex is determined by the absence of
This sex determination is determined at the time of fertilization
Single most consistent determinant of maleness
Presence of Y chromosome
This hypothesis states that one of the 2 copies of the X chromosome present in females is inactivated
Basis of sex chromatin test
Sex determination test that stains the hair strands with fluorescent stain
Used for large populations (Olympics) that ensures the individual joining the female division is a normal genetic female
Hair root test
Sex chomatin test looks for Barr bodies while Hair root test looks for
Most accurate method for sex determination
This term describes the development of primary sex organs in response to genetic sex
At what week of gestation does the fetus have bipotential gonads?
This cell secretes testosterone which controls the development of the Wolffian duct and development of male external genitalia through DHT
What hormone promotes the development of male external genitalia?
What hormone promotes the development of Wolffian duct into accessory structure?
This cell secretes anti mullerian hormone that cause the regression of the mullerian duct
The testis comes from this embryonic structure
What happens to the embryonic cortex upon development of the male gonads?
Formation of Sertoli cells happens during
Formation of Leydig cells occur during
Secretion of testosterone of Leydig cells occurs in response to what hormone
At what AOG is the definitive testes present and secretion of testosterone established?
At what AOG does the testes descend through the inguinal ring?
What hormone does the embryonic ovary secrete?
The embryonic cortex in female development proliferates to become
The ovaries reach maximal development at what AOG
In female gonad development the embryonic medulla regresses and forms the
Hilum of mature ovaries
When does female gonadal development start?
9 weeks when there is absence of signal for testis formation
This type of sex is determined by the regulation of gonadal sex of the differentiation of the genital apparatus
Derivatives of the Wolffian duct
Derivatives of the Paramesonephric duct
Carey Mulligan (Mullerian)
This hormone is required for conversion of testosterone to DHT
5 alpha reductase
Precursor of both external genitalia
Genital tubercle develops into these structures in the male and female external genitalia
Male- glans penis, corpus cavernosum, spongiosum
Female- clitoris and vestibular bulb
Urogenital folds become
Male- ventral shaft of penis
Female- labia minora
Labioscrotal/Genital swelling becomes
Scrotum and prepuce
The urogenital sinus becomes
Male urethra, Cowper, prostate gland
Female urethra, lower vagina, bartholin and skene glands
Transverse vaginal septum occurs when this structure fails to develop
The growth of the labia to normal size requires this hormone
Control of gonadal function is mediated by these 2 gonadotropins
Release of gonadotropins in males are in this manner
Release of gonadotropins in females are in this manner
This type of sex is the establishment of gender role, identity and sexual orientation
This type of error in sex determination occurs when there is an established defect in gametogenesis where chromosomes fail to separate and both go to one daughter cell during meiosis
Most common type of Nondisjunction that leads to complete absence of one sex chromosome and monosomy
Coarctation of aorta
Meiotic nondisjunction that leads to testicular atrophy
Eunuchoid body shape
Tall, long extremities
Genetic males whose target cells lack receptors for testosterone are feminized
Male pseudo hermaphroditism