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Flashcards in Developmental Biology Deck (46):
1

Genetic female sex is determined by the absence of

SRY gene

2

This sex determination is determined at the time of fertilization

Genetic sex

3

Single most consistent determinant of maleness

Presence of Y chromosome

4

This hypothesis states that one of the 2 copies of the X chromosome present in females is inactivated

Basis of sex chromatin test

Lyon hypothesis

5

Sex determination test that stains the hair strands with fluorescent stain

Used for large populations (Olympics) that ensures the individual joining the female division is a normal genetic female

Hair root test

6

Sex chomatin test looks for Barr bodies while Hair root test looks for

Y bodies

7

Most accurate method for sex determination

Karyotyping

8

This term describes the development of primary sex organs in response to genetic sex

Gonadal sex

9

At what week of gestation does the fetus have bipotential gonads?

4-6 weeks

10

This cell secretes testosterone which controls the development of the Wolffian duct and development of male external genitalia through DHT

Leydig cells

11

What hormone promotes the development of male external genitalia?

DHT

12

What hormone promotes the development of Wolffian duct into accessory structure?

Testosterone

13

This cell secretes anti mullerian hormone that cause the regression of the mullerian duct

Sertoli cell

14

The testis comes from this embryonic structure

Embryonic medulla

15

What happens to the embryonic cortex upon development of the male gonads?

Regresses

16

Formation of Sertoli cells happens during

6-7 weeks

17

Formation of Leydig cells occur during

8-9 weeks

18

Secretion of testosterone of Leydig cells occurs in response to what hormone

HCG

19

At what AOG is the definitive testes present and secretion of testosterone established?

9 weeks

20

At what AOG does the testes descend through the inguinal ring?

7-9 months

21

What hormone does the embryonic ovary secrete?

None

22

The embryonic cortex in female development proliferates to become

Ovaries

23

The ovaries reach maximal development at what AOG

20-25 weeks

24

In female gonad development the embryonic medulla regresses and forms the

Hilum of mature ovaries

25

When does female gonadal development start?

9 weeks when there is absence of signal for testis formation

26

This type of sex is determined by the regulation of gonadal sex of the differentiation of the genital apparatus

Phenotypic sex

27

Derivatives of the Wolffian duct

VESt
Vas deferens
Epididymis
Seminal vesicle

28

Derivatives of the Paramesonephric duct

Carey Mulligan (Mullerian)
Fallopian tube
Uterus
Cervix
Upper vagina

29

This hormone is required for conversion of testosterone to DHT

5 alpha reductase

30

Precursor of both external genitalia

Anlagen

31

Genital tubercle develops into these structures in the male and female external genitalia

Male- glans penis, corpus cavernosum, spongiosum
Female- clitoris and vestibular bulb

32

Urogenital folds become

Male- ventral shaft of penis
Female- labia minora

33

Labioscrotal/Genital swelling becomes

Scrotum and prepuce
Labia majora

34

The urogenital sinus becomes

Male urethra, Cowper, prostate gland

Female urethra, lower vagina, bartholin and skene glands

35

Transverse vaginal septum occurs when this structure fails to develop

Urogenital sinus

36

The growth of the labia to normal size requires this hormone

Estrogen

37

Control of gonadal function is mediated by these 2 gonadotropins

FSH
LH

38

Release of gonadotropins in males are in this manner

Tonic

39

Release of gonadotropins in females are in this manner

Cyclic

40

This type of sex is the establishment of gender role, identity and sexual orientation

Psychological sex

41

This type of error in sex determination occurs when there is an established defect in gametogenesis where chromosomes fail to separate and both go to one daughter cell during meiosis

Nondisjunction

42

Most common type of Nondisjunction that leads to complete absence of one sex chromosome and monosomy

Turner syndrome

43

Streaked ovary
Short stature
Shield chest
Coarctation of aorta

Turner syndrome

44

Meiotic nondisjunction that leads to testicular atrophy
Eunuchoid body shape
Tall, long extremities
Gynecomastia

Klinefelter

45

Genetic males whose target cells lack receptors for testosterone are feminized

Male pseudo hermaphroditism

Androgen insensitivity

46

Virilization of XX fetus
Ambiguous genitalia
Adrenal androgen overproduction

Congenital adrenal hyperplasia