Diabetes medications Flashcards Preview

STEP1 2014 > Diabetes medications > Flashcards

Flashcards in Diabetes medications Deck (19):
1

lactic acidosis is a rare but worrisome side effect

metformin

2

most common side effect is hypoglycemia

sulfonylureas

3

recommended first- line treatment for most patients

metformin

4

not safe in the setting of hepatic dysfunction or CHF

thiazolidinediones (TZDs)

5

should not be used in patients with elevated serum creatinine

metformin

6

should not be used in patients with cirrhosis or inflammatory bowel disease

alpha- glucosidase inhibitors

7

not associated with weight gain

metformin, DPP4 inhibitors, GLP-1 analogs

8

metabolized by the liver; excellent choice in patients with renal disease

thiazolidinediones

9

closes potassium channel on beta cells so that they depolarize, calcium influx; insulin release

sulfonylureas

10

inhibits alpha- glucosidease at the intestinal brush border

alpha- glucosidase inhibitors

11

agonist at PPAR-gamma receptors, improved target cell response to insulin

thiazolidinediones

12

decreases hepatic gluconeogenesis

metformin

13

good for weight loss

GLP1 analog

14

avoid in hypoglycemia

sulfonylureas

15

best treatment for anyone with organ failure (renal, liver, heart)

insulin

16

DDx for DKA (events that increase glucagon, catecholamines, or corticosteroids in circulation)

infection
diabetic medication reduction or ommission
severe medical illness (MI, CVA, trauma)
undiagnosed DM
dehydration
alcohol or drug abuse (stimulants)
corticosteroids

17

standard treatment for DKA

IV fluids, IV insulin, potassium replacement

18

standard treatment for type 1 DM

exogenous insulin

19

standard treatment for type 2 DM

low carb diet, weightloss, oral hypoglycemic drugs, insulin