Side effects

Question 1

CV: cutaneous flushing

Answer 1

vancomycin
niacin (B3)
adenosine
dihydropyridine CCB

Question 2

CV: vasospasm

Answer 2

cocaine
amphetamines
methamphetamines
-triptans
ergotamines

Question 3

CV: Dilated cardiomyopathy

Answer 3

dexorubicin
donorubicin
cardiotoxicity and bone marrow suppression because these are anti- cancer drugs

Question 4

CV: Torsades de pointes

Answer 4

Tx: MgSO4
QT interval prolongation:
Class 3 antiarrhythmics which are potassium channel blockers
Class 1a antiarrythmics, which are sodium channel blockers (macrolides, haloperidol, chloroquine, protease inhibitors)

Question 5

Hematology: thrombocytopenia

Answer 5

heparin

cimetadine (H2 blocker)

Question 6

Hematology: Agranulocytosis

Answer 6

Clozapine
Carbamazepine
Colchicine
PTU
Methimazole
Dapsone

Question 7

Hematology: aplastic anemia

Answer 7

Chloramphenicol
Benzene
NSAIDs
PTU
Methimazole

Question 8

Hematology: Gray baby syndrome

Answer 8

Chloramphenicol (UDP glucoronyl- transferase is underactive in babies)

Question 9

Hematology: hemolysis in G6PD- deficient patients

Answer 9

isoniazid
sulfonamides
primaquine
high- dose aspirin
ibuprofen
nitrofurantoin
dapsone
fava beans
naphthalene

Question 10

Hematology: thrombosis

Answer 10

OCPs, especially in a smoker older than 35 years

Question 11

Respiratory: pulmonary fibrosis

Answer 11

amiodarone
bleomycin
busulfan

Question 12

Respiratory: cough

Answer 12

ACEI

a tickly cough mediated by bradykinin

Question 13

GI: pseudomembranous colitis

Answer 13

clindamycin

amoxicillin/ ampicillin

Question 14

GI: focal to massive hepatic necrosis

Answer 14

halothane
acetaminophen
valproic acid
amanita phalloides (mushroom toxin)

Question 15

GI: hepatitis

Answer 15

INH

Question 16

Endocrine: gynecomastia

Answer 16

Some drugs create awesome knockers:

spironolactone
digoxin
estrogen
cimetadine
chronic alcohol
ketoconazole
marijuana

Question 17

Endocrine: adrenocortical insufficiency

Answer 17

withdrawal of corticosteroids

Question 18

Endocrine: hot flashes

Answer 18

tamoxifen

clomiphene

Question 19

Endocrine: Hypothyroidism

Answer 19

amiodarone (contains iodine)
lithium
sulfonamides

Question 20

MSK: gout

Answer 20

furosemide
thiazides
niacin
cyclosporin
pyrazinamide

Question 21

MSK: gingival hyperplasia

Answer 21

phenytoin

verapamil

Question 22

MSK: osteoporosis

Answer 22

corticosteroids

heparin

Question 23

MSK: photosensitivity

Answer 23

SAT (in the sun)
sulfonamides
amiodarone
tetracycline

Question 24

MSK: SJS

Answer 24

seizure drugs:
ethosuxamide
carbamazepine
lamotrigine
phenytoin
phenobarbitol

Sulfa drugs
Penicillin
Allopurinol

Question 25

MSK: Drug induced lupus (check anti- histone ab)

Answer 25

``` SHIPP Sulfonamides Hydralazines Isoniazid Procainamide Phenytoin ```

Question 26

MSK: tendon rupture/ cartilage damage

Answer 26

Fluoroquinolones

Question 27

Renal: Interstitial nephritis

Answer 27

NSAIDs furosemide antibiotics

Question 28

Renal: DI note: treat renal DI with HCTZ (improper kidney response to ADH)

Answer 28

Lithium | Demeclocycline

Question 29

Renal: Fanconi proximal tubule defect where protein is spilled

Answer 29

Expired tetracycline | Heavy metal exposure

Question 30

Hemorrhagic cystitis

Answer 30

Cyclophosphamide | Ifosfamide

Question 31

Neuro: Parkinson- like

Answer 31

Metoclopramide Antipsychotics Reserpine

Question 32

Neuro: cinchonism (dizziness with HA, vision changes, tinnitus)

Answer 32

Quinidine | Quinine

Question 33

Neuro: seizures

Answer 33

``` Buproprion Imipenem/cilastin INH Tramadol Metoclopramide Benzodiazepine/alcohol withdrawal ```

Question 34

Neuro: Tardive dyskinesia

Answer 34

Antipsychotics

Question 35

Multiorgan: Disulfiram- like reaction

Answer 35

``` Metronidazole Certain Cephalosporins Procarbazine First gen sulfonylureas Disulfiram ```

Question 36

Nephrotoxicity and neurotoxicity

Answer 36

Aminoglycosides Cisplatin Polymixin

Question 37

Nephrotoxicity and ototoxicity

Answer 37

Aminoglycosides Vancomycin Loop diuretics Cisplatin

Question 38

``` Anticholinergic effects Dry as a bone Hot as a hare Red as a beet Blind as a bat Mad as a hatter Bloated as a toad ```

Answer 38

``` Atropine TCAs H1 Blockers Thioridizine Chlorpromazine ``` avoid in patients with delirium, dementia, BPH pts

Question 39

Lithium

Answer 39

LMNOP Lithium side effects: Movement (Tremor) Nephrogenic DI because Lithium blocks ADH Hypothyroidism Pregnancy problems (teratogenic- Ebstein anomaly and malformation of the great vessels)