Side effects Flashcards Preview

STEP1 2014 > Side effects > Flashcards

Flashcards in Side effects Deck (39):
1

CV: cutaneous flushing

vancomycin
niacin (B3)
adenosine
dihydropyridine CCB

2

CV: vasospasm

cocaine
amphetamines
methamphetamines
-triptans
ergotamines

3

CV: Dilated cardiomyopathy

dexorubicin
donorubicin
cardiotoxicity and bone marrow suppression because these are anti- cancer drugs

4

CV: Torsades de pointes

Tx: MgSO4
QT interval prolongation:
Class 3 antiarrhythmics which are potassium channel blockers
Class 1a antiarrythmics, which are sodium channel blockers (macrolides, haloperidol, chloroquine, protease inhibitors)

5

Hematology: thrombocytopenia

heparin
cimetadine (H2 blocker)

6

Hematology: Agranulocytosis

Clozapine
Carbamazepine
Colchicine
PTU
Methimazole
Dapsone

7

Hematology: aplastic anemia

Chloramphenicol
Benzene
NSAIDs
PTU
Methimazole

8

Hematology: Gray baby syndrome

Chloramphenicol (UDP glucoronyl- transferase is underactive in babies)

9

Hematology: hemolysis in G6PD- deficient patients

isoniazid
sulfonamides
primaquine
high- dose aspirin
ibuprofen
nitrofurantoin
dapsone
fava beans
naphthalene

10

Hematology: thrombosis

OCPs, especially in a smoker older than 35 years

11

Respiratory: pulmonary fibrosis

amiodarone
bleomycin
busulfan

12

Respiratory: cough

ACEI
a tickly cough mediated by bradykinin

13

GI: pseudomembranous colitis

clindamycin
amoxicillin/ ampicillin

14

GI: focal to massive hepatic necrosis

halothane
acetaminophen
valproic acid
amanita phalloides (mushroom toxin)

15

GI: hepatitis

INH

16

Endocrine: gynecomastia

Some drugs create awesome knockers:

spironolactone
digoxin
estrogen
cimetadine
chronic alcohol
ketoconazole
marijuana

17

Endocrine: adrenocortical insufficiency

withdrawal of corticosteroids

18

Endocrine: hot flashes

tamoxifen
clomiphene

19

Endocrine: Hypothyroidism

amiodarone (contains iodine)
lithium
sulfonamides

20

MSK: gout

furosemide
thiazides
niacin
cyclosporin
pyrazinamide

21

MSK: gingival hyperplasia

phenytoin
verapamil

22

MSK: osteoporosis

corticosteroids
heparin

23

MSK: photosensitivity

SAT (in the sun)
sulfonamides
amiodarone
tetracycline

24

MSK: SJS

seizure drugs:
ethosuxamide
carbamazepine
lamotrigine
phenytoin
phenobarbitol

Sulfa drugs
Penicillin
Allopurinol

25

MSK: Drug induced lupus (check anti- histone ab)

SHIPP
Sulfonamides
Hydralazines
Isoniazid
Procainamide
Phenytoin

26

MSK: tendon rupture/ cartilage damage

Fluoroquinolones

27

Renal: Interstitial nephritis

NSAIDs
furosemide
antibiotics

28

Renal: DI
note: treat renal DI with HCTZ (improper kidney response to ADH)

Lithium
Demeclocycline

29

Renal: Fanconi proximal tubule defect where protein is spilled

Expired tetracycline
Heavy metal exposure

30

Hemorrhagic cystitis

Cyclophosphamide
Ifosfamide

31

Neuro: Parkinson- like

Metoclopramide
Antipsychotics
Reserpine

32

Neuro: cinchonism (dizziness with HA, vision changes, tinnitus)

Quinidine
Quinine

33

Neuro: seizures

Buproprion
Imipenem/cilastin
INH
Tramadol
Metoclopramide
Benzodiazepine/alcohol withdrawal

34

Neuro: Tardive dyskinesia

Antipsychotics

35

Multiorgan: Disulfiram- like reaction

Metronidazole
Certain Cephalosporins
Procarbazine
First gen sulfonylureas
Disulfiram

36

Nephrotoxicity and neurotoxicity

Aminoglycosides
Cisplatin
Polymixin

37

Nephrotoxicity and ototoxicity

Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin

38

Anticholinergic effects
Dry as a bone
Hot as a hare
Red as a beet
Blind as a bat
Mad as a hatter
Bloated as a toad

Atropine
TCAs
H1 Blockers
Thioridizine
Chlorpromazine

avoid in patients with delirium, dementia, BPH pts

39

Lithium

LMNOP
Lithium side effects:
Movement (Tremor)
Nephrogenic DI because Lithium blocks ADH
Hypothyroidism
Pregnancy problems (teratogenic- Ebstein anomaly and malformation of the great vessels)