Diseases of the Ovary 2

Question 1

95% of germ cell tumors are ______

Answer 1

bening cystic teratomas

Question 2

mature/immature teratom is benign

Answer 2

mature; immature has neoplastic potential

Question 3

what are three specialized teratomas?

Answer 3

• struma ovaria: hyperthyroidism
• carcinoid tumor: carcinoid syndrome
• strumal carcinoid: mix of the above two

Question 4

struma ovarii presents with features of _______

Answer 4

HYPERthryoidism

Question 5

schiller Duval bodies are found in an ovarian tumor. What cell is the origin of this tumor?

Answer 5

Schiller Duval bodies are layers of epithelial cells around blood vessels that resemble glomeruli and are found in endodermal sinus tumor (yolk sac tumor) which is a germ cell tumor

Question 6

dysgerminoma most commonly presents in _______ (demographic)

Answer 6

young kids or women

Question 7

tumor analysis of the ovary shows a homogenous grape pink, soft fleshy tumor and on histology it shows large uniform round cells with clear cytoplasm, central nuclei and no stroma. “fried egg appearance”
what is the best method of treatment for this condition

Answer 7

diagnosis: dysgerminoma

very chemosensitive so treat with chemotherapy

Question 8

a ovarian tumor that secrets β hCG is ________

Answer 8

choriocarcinoma (non gestational)

Question 9

biopsy of ovarian tumor shows glomeruli likes cells. What is the most likely diagnosis and what tumor marker would be elevated

Answer 9

diagnosis: endodermal sinus tumor; ↑ AFP

Question 10

carl Exner bodies are seen in _________

Answer 10

granulosa cell tumors

Question 11

______ is a tumor marker used to diagnose granuloma cell tumors

Answer 11

inhibin

Question 12

what are the three components of Meig’s syndrome

Answer 12

• ascites
• right sided hydrothorax
• fibroma of the ovary

Question 13

_________ tumors have Reinke crystals on histology

Answer 13

pure leydig cell tumors

Question 14

what is the most common malignant ovarian lesion?

Answer 14

serous adenocarcinoma (it is also the most common bilateral ovarian tumor)

Question 15

granulomas / theca cell tumor is malignant

Answer 15

granuloma cell tumor is the most common malignant stromal tumor (commonly seen in women in their 50’s)

Question 16

contrast the histology presentation of granulosa and theca cell tumors

Answer 16

• granulosa: call Exner bodies which are granulosa cells arranged in small follicles filled with eosinophilic secretions in the center
• theca: cells with abundant lipid filled cytoplasm and grossly will be solid yellow tumors

Question 17

pleomorphic, giant cells and multinucleartion and is highly fatal with early and widespread metastasis especially to the lungs, liver and viscera is descriptive of ________

Answer 17

choriocarcinoma

Question 18

what makes ovarian choriocarcinoma different from uterine and placental choriocarcinoma?

Answer 18

ovarian choriocarcinoma does NOT respond to chemotherapy;
choriocarcinoma is a malignant epithelial tumor composed of anaplastic cytotrophoblasts and syncytiotrophoblasts without chorionic villi and it spreads hematogenously

Question 19

patient with late post partum bleeding and SOB and hemoptysis are common symptoms with someone with what malignant tumor? what serum marker would be elevated?

Answer 19

choriocarcinoma; cannot treat with chemotherapy

↑ β HCG

Question 20

gonadoblastoma is a mixture of what two types of tumors?

Answer 20

germ cell tumor + sex cord tumor

Question 21

_______ is the most common form of ovarian metastatic carcinoma in young women; what is the prognosis?

Answer 21

Krukenberg tumor; poor prognosis