Hypothalamic and Pituitary Hormones Flashcards
pulsatile release of GnRH will cause _______
stimulates the release of LH and FSH (must be PULSATILE)_
sustained NONpulsatile GnRH release will _____ FSH and LH release
inhibit; (leads to hypogonadism)
______ (drug) is a diagnostic tool for differentiating between primary adrenal insufficiency (Addison’s) and secondary adrenal insufficiency (inadequate ACTH production)
corticotropin/cosyntropin
oxytocin acts on GPCR’s that stimulates the release of ______ and _____ that augment uterine contractions
prostaglandins and leukotrienes
menotropins are purified extract of FSH and LH from what type of women
post menopausal women
FSH/LH is important for spermatogenesis and the conversion of testosterone to estrogen
FSH
what are two clinical applications for the use of bromocriptine/cabergoline?
- both are dopamine agaonists
- treat hyperprolactinemia
- treat acromegaly
V__ subtype of the ADH receptor is found on the vascular smooth muscles and cause Vascoconstrictoin
V1
mecasermin is a ______ analog
IGF-1 (insulin like growth factor 1)
which of the dopamine agonists (bromocriptine and cabergoline) have the longer half life
cabergoline
vasopressin/desmopressin is given to treat esophageal farcical bleeding
vasopressin
what are some AE of gonadorelin?
GnRH receptor agonists
- generalized HS
- sudden pituitary apoplexy (bleeding into/impaired blood supply at pituitary gland) and blindness
which subtype of the ADH receptor is found on the renal tubules?
V2
vasopressin/desmopressin is given for the coagulopathy treatment of Hemophilia A and Vw disease
desmopressin;
Desmopressin also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.
which subtype of the receptor does desmopressin have the most effect?
V2; minimal V1 effects
