Thyroid Pathology Flashcards
what antibodies do you see in Hashimoto’s thyroiditis?
- antimicrosomal / antithyroid peroxidase
- antithyroglobulin
what is the most common thyroid malignancy?
papillary
what thyroid condition is characterized by HLA associated antibody mediated immune destruction of thyroid cells?
Hashimoto’s Thyroiditis
_______ carcinoma of the thyroid has the WORST prognosis
anaplastic
patient presents with ↑ antithyroglobulin antibodies; what is the most likely diagnosis
Hashimoto’s thyroiditis
which of the thyroid carcinomas RARELY involves lymph nodes
follicular; it invades the capsules and spreads into the blood vessels
papillary tends to spread to lymph nodes
________ (thyroid condition) may be associated with endothelial dysfunction (first lesion for atherosclerosis) and can lead to atheroma
sub clinical hypothyroidism
↑ antimicrosomal, antithyroid peroxidase and and antithyroglobulin antibodies are present in high titers. Diagnosis?
Hashimoto’s
medullary carcinoma of the thyroid can lead to _____ (calcium levels)
hypocalcemia (↑ calcitonin)
the most common cause of hypothyroidism in the US is ______
Hashimoto’s thyroiditis; characterized by HLA associated antibody mediated destruction of thyroid cells
thyroid stimulating immunoglobulins (TSI) are seen in Grave’s/Hashimoto’s?
Grave’s
Hashimoto’s thyroiditis puts patients at an increased risk for what hematological condition?
- ↑ risk for thyroid B cell lymphoma
hyperprolactinemia is a clinical feature of ______thyroidism
hypothyroidism; TRH stimulates secretion of prolactin and in hypothyroidism patients, they will have ↑ TRH
what are 4 main causes of hyperthyroidism?
- diffuse hyperplasia (Grave’s disease)
- toxic adenoma
- toxic multi nodular goiter
- thyroiditis: post partum thyroiditis due to natural immunosuppression during pregnancy
Grave’s disease causes ____thyroidism
hyperthyroidism
